Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain

The Journal of Comparative Neurology
Tetsushi SadakataTeiichi Furuichi

Abstract

The Ca(2+)-dependent activator protein for secretion (CAPS/Cadps) family consists of two members, CAPS1 and CAPS2, and plays an important role in secretory granule exocytosis. It has been shown that CAPS1 regulates catecholamine release from neuroendocrine cells, whereas CAPS2 is involved in the release of two neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), from parallel fibers of cerebellar granule cells. Although both CAPS proteins are expressed predominantly in the brain, their cellular and regional distributions in the brain are largely unknown. In this study we analyzed the immunohistochemical distributions of the CAPS family proteins in the mouse brain. In most areas of the embryonic nervous system CAPS1 and CAPS2 proteins were complementarily expressed. In the postnatal brain, CAPS1 was widespread at different levels. On the other hand, CAPS2 was localized to distinct cell types and fibers of various brain regions, including the olfactory bulb, cerebrum, hippocampal formation, thalamus, mesencephalic tegmentum, cerebellum, medulla, and spinal cord, except for some regions that overlapped with CAPS1. These CAPS2 cellular distribution patterns had the marked feature of coinciding with tho...Continue Reading

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Citations

Jan 23, 2009·Molecular Neurobiology·David R Stevens, Jens Rettig
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tetsushi SadakataTeiichi Furuichi
Mar 24, 2007·The Journal of Clinical Investigation·Tetsushi SadakataTeiichi Furuichi
Sep 19, 2012·Cellular and Molecular Life Sciences : CMLS·Natalie Porat-ShliomRoberto Weigert
Mar 23, 2010·Neuroscience Research·Tetsushi Sadakata, Teiichi Furuichi
Nov 5, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wendy H RaskindThomas D Bird
May 16, 2014·The Journal of Comparative Neurology·Rémy PujolJennifer S Stone
Aug 12, 2006·Neuroscience Letters·Tetsushi Sadakata, Teiichi Furuichi
Oct 18, 2011·Biological Psychology·Kotaro HattoriHiroshi Kunugi
May 24, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kotaro HattoriHiroshi Kunugi
Nov 21, 2007·Cell·Wolf J JockuschNils Brose
Dec 14, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tetsushi SadakataTeiichi Furuichi
Jun 26, 2017·Biochemical and Biophysical Research Communications·Julia ObergasteigerMattia Volta
Sep 19, 2020·Cell and Tissue Research·Tanja Brigadski, Volkmar Leßmann
Nov 15, 2008·The Journal of Biological Chemistry·Irene BrunkGudrun Ahnert-Hilger

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