PMID: 6405435Jan 1, 1983Paper

Differential dose-response effects of dexamphetamine sulphate on hunger, arousal and mood in human volunteers

Psychopharmacology
T SilverstoneE Trenchard

Abstract

The effect of dexamphetamine (d-Amp) and placebo on visual analogue scale (VAS) ratings of hunger, arousal and mood in nine male volunteers was observed. d-Amp (10 mg) significantly depressed hunger ratings but did not significantly affect arousal and mood ratings. d-Amp (20 mg) had a significant effect on all three ratings. There was a difference in the pattern of dose-response effects. Whereas 20 mg d-Amp produced greater changes than 10 mg in ratings of mood and arousal, there was no significant difference on ratings of hunger. These differences in dose-response relationships may reflect differences in the underlying neurochemical mechanisms mediating the stimulant and anorectic effects of d-Amp.

References

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Citations

Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·G D Carr, N M White
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·P J Fudala, E T Iwamoto
Jan 1, 1982·Pharmacology & Therapeutics·T Silverstone
May 1, 1985·Journal of Affective Disorders·T Silverstone
Feb 1, 1992·Psychiatry Research·B AdinoffM Linnoila
Feb 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·K N Sokolski, E M Demet
Jun 14, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Morgan C WillsonPeter H Silverstone
May 1, 1986·Psychological Medicine·D Jacobs, T Silverstone
Jul 2, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Krista L LanctôtUsoa E Busto
Oct 24, 2007·Pharmacology & Therapeutics·John D Fernstrom, Sujean Choi
Jun 1, 1986·Drug and Alcohol Dependence·T Silverstone
Mar 15, 1989·Biological Psychiatry·D A KahnH A Sackeim
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seo Yeon Park, Ung Gu Kang
May 1, 1983·Psychological Medicine·T Silverstone

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