Differential durability of immune responses to measles and mumps following MMR vaccination

Vaccine
Richard B KennedyG A Poland

Abstract

The development and wide-spread use of mumps vaccine resulted in a dramatic and sustained decrease in the incidence of mumps disease; however, since 2000, an increase in the size and number of mumps outbreaks in the United States and other countries has sparked renewed interest in the durability of mumps-specific immunity elicited by mumps vaccination. The most likely explanation for mumps cases in previously immunized persons may be secondary vaccine failure, or waning immunity. In the current study, we examined changes in markers of measles and mumps immunity at two timepoints, approximately 7 and 17 years after two-dose MMR-II® vaccination, in a cohort of 98 healthy adults. Our results indicate that mumps IgG titers exhibited a large and significant decline during this time period, while mumps neutralizing Ab titers were relatively stable. There was a similar discrepancy with measles-specific immune responses. For both pathogens, neutralizing antibody titers were fairly low and, given the length of time since vaccination, may have already declined. These data suggest that specific immune outcomes may wane at different rates and highlight our currently incomplete understanding of protective immune responses to mumps and measles.

Citations

Oct 19, 2019·European Journal of Epidemiology·Emilie JavelleDidier Raoult
Aug 28, 2020·Frontiers in Immunology·Svetlana VakkilainenPaula Klemetti
May 22, 2019·The Journal of Infectious Diseases·Patricia KaaijkRob S van Binnendijk
Mar 29, 2020·BMC Infectious Diseases·Talal El ZarifAbdul Rahman Bizri
Jul 17, 2020·Frontiers in Immunology·Richard B KennedyGregory A Poland
Oct 20, 2020·Frontiers in Immunology·Anna R ConnellJaythoon Hassan
Jan 19, 2021·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Ricardo R Bartelme
Nov 17, 2020·Global Pediatric Health·Lankala M ReddyClaudia R Morris
Jan 23, 2021·Biomedicines·Claudia FerlitoRaffaele D'Amelio
Mar 11, 2021·Human Vaccines & Immunotherapeutics·Seung Beom HanSoyoung Shin
Nov 17, 2020·Vaccine·Stephen N CrookeRichard B Kennedy
May 1, 2021·Vaccines·Andrea TrevisanMaria Luisa Scapellato

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