Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice

Journal of Neuroinflammation
M Florencia IulitaHélène Girouard

Abstract

Angiotensin II (Ang II), a peptide hormone involved in the development of hypertension, causes systemic and cerebral inflammation, affecting brain regions important for blood pressure control. The cause-and-effect relationship between hypertension and inflammation is two-way, but the role of blood pressure in the induction of cerebral inflammation is less clear. The vulnerability of specific brain regions, particularly those important for memory, is also of interest. We used molecular biology approaches, immunohistochemistry, and electron microscopy to examine the interdependence between the hypertensive and pro-inflammatory effects of Ang II. We examined the effect of blood pressure by administering a subpressive (200 ng/kg/min) or a pressive Ang II dose (1000 or 1900 ng/kg/min) with and without hydralazine (150 mg/L) for 1 week and used phenylephrine to increase blood pressure independently of the renin-angiotensin system. Ang II increased ionized calcium-binding adaptor molecule 1 (Iba-1) levels (marker of microgliosis) in the whole brain and in the hippocampus in a dose-dependent manner. Pressive Ang II induced specific changes in microglial morphology, indicating differences in functional phenotype. An increase in hippocam...Continue Reading

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Citations

Apr 18, 2019·Journal of Neuroinflammation·Hassan El HajjMarie-Ève Tremblay
Dec 24, 2018·Journal of the American Heart Association·M Florencia IulitaHélène Girouard
Mar 22, 2019·Nature Reviews. Cardiology·Laura CalvilloGianfranco Parati
Aug 20, 2019·The European Journal of Neuroscience·Katarzyna A DudekCaroline Menard
Sep 22, 2020·Pharmacology & Therapeutics·Jason D Vadhan, Robert C Speth
Jun 18, 2021·American Journal of Hypertension·Jessica Youwakim, Hélène Girouard
Aug 31, 2021·Journal of the American Heart Association·Michaël BoilyHélène Girouard

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Methods Mentioned

BETA
transgenic
electrophoresis
PCR
electron microscopy
ELISA

Software Mentioned

ImageJ
GraphPad Prism

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