PMID: 9166121May 1, 1997Paper

Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients

The Journal of Endocrinology
J GeislerP E Lønning

Abstract

Steroid sulphates such as oestrone sulphate (OE1S) and dehydroepiandrosterone sulphate (DHEAS) have been suggested to be of biological importance in different disease states such as breast cancer and atherosclerosis. Previous studies have shown that drugs such as aminoglutethimide and rifampicin that induce P450-dependent mixed-function oxygenases selectively suppress plasma OE1S levels. The aim of this study was to evaluate the influence of treatment with carbamazepine, an antiepileptic drug known to stimulate mixed-function oxygenases, on plasma levels of OE1S and DHEAS. We measured plasma OE1S and DHEAS together with other plasma oestrogens and androgens in male epileptic patients before and during carbamazepine monotherapy. Patients treated with valproate monotherapy acted as a control group. Treatment with carbamazepine decreased plasma OE1S levels from a mean value of 810.8 to 411.6 pmol/l (mean suppression to 50.7% of pretreatment levels, P < 0.001). Similarly, the ratio of OE1S to OE1 fell to 59.9% of pretreatment levels (P < 0.001)). DHEAS decreased from a mean level of 4.9 mumol/l before treatment to 3.0 mumol/l during carbamazepine therapy (mean reduction to 62.7% of pretreatment levels (P < 0.001), while the ratio o...Continue Reading

Citations

Nov 15, 2011·Breast Cancer Research and Treatment·Michaela J HigginsVered Stearns
Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wattana Leowattana
Feb 28, 2002·Journal of Clinical Pharmacology·Firoozeh S SalekPatricia Dowley Kroboth
Apr 10, 1999·Journal of Clinical Pharmacology·P D KrobothR F Frye
Aug 6, 2016·Seizure : the Journal of the British Epilepsy Association·Mustafa CeylanAli Rıza Sonkaya
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jürgen GeislerPer Eystein Lønning
Jun 1, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alberto VerrottiFrancesco Chiarelli

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