Differential effect of DHEA on mitogen-induced proliferation of T and B lymphocytes

The Journal of Steroid Biochemistry and Molecular Biology
Yuji SakakuraTakehiko Ohzeki

Abstract

Dehydroepiandrosterone (DHEA) is the predominant steroid hormone secreted by adrenal gland, and it has been proposed in recent years that DHEA has significant effects on immune function. We investigated the effect of DHEA (1 x 10(-5) - 1 x 10(-8)M) on proliferation of human T cells and B cells and on immunoglobulin production, a representative function of B cells. High doses of DHEA (1 x 10(-5)) significantly inhibited proliferation of peripheral blood mononuclear cells (PBMCs) and T cells induced by T cell mitogens hemagglutinin (PHA) and concanavalin A (Con A). Proliferation of PBMCs induced by B cell mitogens pokeweed mitogen (PWM) was increased by 1 x 10(-7) - 1 x 10(-6)M DHEA. Proliferation of PBMCs and B cells induced by Staphylococcus aureus Cowan strain I (SAC) was not significantly changed at any concentrations of DHEA. However, a concentration of 1 x 10(-7)M DHEA tended to potentiate their proliferation. This study suggested that DHEA acted on T and B lymphocytes differentially in immune system.

References

May 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A W MeikleR A Daynes
Mar 1, 1995·The Journal of Antimicrobial Chemotherapy·J E Rehg
Jul 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·R Morfin, G Courchay
Dec 29, 1995·Annals of the New York Academy of Sciences·A Vermeulen
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·O KhorramS S Yen
Feb 5, 2000·The Journal of Endocrinology·M SchmidtR H Straub
Feb 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·I SterzlL Stárka
Jun 7, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G F Cheng, J Tseng
Sep 13, 2002·Journal of Neuroimmunology·Halina OffnerChristopher L Reading

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Citations

Jan 4, 2013·Biogerontology·Moisés E BauerJos A Bosch
Feb 23, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T BroccolettiC Pignata
Apr 2, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sean P Prall, Michael P Muehlenbein
Mar 3, 2015·American Journal of Primatology·Sean P PrallMichael P Muehlenbein
Jan 12, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Jon HazeldineJanet M Lord
Jun 16, 2015·BioMed Research International·Guadalupe Veronica SuarezMaria Florencia Quiroga
May 19, 2009·Veterinary Parasitology·Leony Cristina CaetanoJosé Clóvis do Prado Júnior
Jun 28, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Carolyn R Hodges-SimeonSteven J C Gaulin
Sep 1, 2007·Current Opinion in HIV and AIDS·Heather B Jaspan, Willem A Hanekom

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