Differential Effect of Glycosylated Hemoglobin Value and Antidiabetic Treatment on the Risk of 30-day Readmission Following a Hospitalization for Acute Heart Failure

Revista Española De Cardiología
Julio NúñezJosé Real

Abstract

In patients with heart failure and type 2 diabetes, low glycosylated hemoglobin has been related with higher risk of mortality but information regarding morbidity is scarce. We sought to evaluate the association between glycosylated hemoglobin and 30-day readmission in patients with type 2 diabetes and acute heart failure. Glycosylated hemoglobin was measured before discharge in 835 consecutive patients with acute heart failure and type 2 diabetes. Cox regression analysis adapted for competing events was used. Mean (standard deviation) age was 72.9 (9.6) years and median glycosylated hemoglobin was 7.2% (6.5%-8.0%). Patients treated with insulin or insulin/sulfonylurea/meglitinides were 41.1% and 63.2% of the cohort, respectively. At 30 days post-discharge, 109 (13.1%) patients were readmitted. A multivariate analysis revealed that the effect of glycosylated hemoglobin on the risk of 30-day readmission was differentially affected by the type of treatment (P for interaction<.01). Glycosylated hemoglobin (per 1% decrease) was inversely associated with higher risk in those receiving insulin (hazard ratio = 1.45; 95% confidence interval, 1.13-1.86; P=.003) or insulin/sulfonylurea/meglitinides (hazard ratio = 1.44; 95% confidence in...Continue Reading

References

Feb 24, 2001·Medical Decision Making : an International Journal of the Society for Medical Decision Making·E W SteyerbergJ D Habbema
Jul 16, 2008·Archives of Internal Medicine·Joseph S RossHarlan M Krumholz
Jul 25, 2009·Journal of the American College of Cardiology·David AguilarAnita Deswal
Jan 26, 2011·Circulation·Natalia Yakubovich, Hertzel C Gerstein
May 6, 2011·Diabetes Care·Brian M FrierSimon R Heller
Mar 31, 2012·The American Journal of Cardiology·G Sofia TomovaTamara B Horwich
Jul 24, 2012·Journal of the American College of Cardiology·Javed Butler, Andreas Kalogeropoulos
Jan 24, 2013·JAMA : the Journal of the American Medical Association·Muthiah VaduganathanMihai Gheorghiade
Jan 24, 2013·JAMA : the Journal of the American Medical Association·Kumar DharmarajanHarlan M Krumholz
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Paul M RindlerLuke I Szweda
Aug 1, 2013·BMJ : British Medical Journal·Atsushi GotoMitsuhiko Noda
Sep 24, 2013·Cardiovascular Diabetology·Markolf HanefeldPeter Bramlage
Oct 8, 2013·American Heart Journal·Marco D HueschGregg C Fonarow
Dec 30, 2014·The Journal of Thoracic and Cardiovascular Surgery·Hersh Maniar
Apr 2, 2016·Scandinavian Journal of Statistics, Theory and Applications·Peng HeMei-Jie Zhang

❮ Previous
Next ❯

Citations

Feb 6, 2017·Cardiovascular Research·Elizabeth MurphyJunhui Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

The American Journal of Medicine
Mikhail KosiborodHarlan M Krumholz
Diabetic Medicine : a Journal of the British Diabetic Association
E J BoykoD Davignon
© 2021 Meta ULC. All rights reserved