Differential effect of Helicobacter pylori eradication on time-trends in brady/hypokinesia and rigidity in idiopathic parkinsonism.

Helicobacter
Sylvia M DobbsDale W Peterson

Abstract

We examine the effect of eradicating Helicobacter in idiopathic parkinsonism (IP). Marked deterioration, where eradication-therapy failed, prompted an interim report in the first 20 probands to reach de-blinding. The null-hypothesis, "eradication has no effect on principal outcome, mean stride length at free-walking speed," was rejected. We report on study completion in all 30 who had commenced post-treatment assessments. This is a randomized, placebo-controlled, parallel-group efficacy study of eradicating biopsy-proven (culture and/or organism on histopathology) Helicobacter pylori infection on the time course of facets of IP, in probands taking no, or stable long-t(1/2), anti-parkinsonian medication. Persistent infection at de-blinding (scheduled 1-year post-treatment) led to open active eradication-treatment. Stride length improved (73 (95% CI 14-131) mm/year, p = .01) in favor of "successful" blinded active over placebo, irrespective of anti-parkinsonian medication, and despite worsening upper limb flexor rigidity (237 (57-416) Nm x 10(-3)/year, p = .01). This differential effect was echoed following open active, post-placebo. Gait did not deteriorate in year 2 and 3 post-eradication. Anti-nuclear antibody was present in a...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·J M RhodesD P Jewell
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1992·Annals of Neurology·D B CalneC Lee
Jul 1, 1990·British Journal of Clinical Pharmacology·S G BowesR J Dobbs
Aug 1, 1993·Statistics in Medicine·P R Freeman
Apr 1, 1993·Acta Neurologica Scandinavica·R J DobbsS M Dobbs
Feb 22, 1997·BMJ : British Medical Journal·J M Bland, D G Altman
Mar 21, 1998·Age and Ageing·A CharlettR J Dobbs
Mar 28, 1998·Acta Neurologica Scandinavica·A CharlettS M Dobbs
Jul 23, 1999·Acta Neurologica Scandinavica·R J DobbsD W Peterson
Aug 17, 1999·Journal of Clinical Microbiology·J C AthertonM J Blaser
Aug 6, 2000·Medical Hypotheses·S M DobbsA Charlett
Sep 29, 2000·Parkinsonism & Related Disorders·D B Calne
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·V Vonka
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jul 10, 2003·Lancet Neurology·Ronald F Pfeiffer
Jun 5, 1965·The Medical Journal of Australia·R R STRANG
Apr 15, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Shin-ichiro KuboYoshikuni Mizuno
Dec 7, 2007·Clinical Neuroscience Research·R Lee MosleyHoward E Gendelman
Mar 7, 2008·Neuro-degenerative Diseases·Benjamin WolozinMisha Riley
May 14, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takashi ItoYoshinobu Eishi
Nov 14, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Jeffrey H KordowerThomas B Freeman
Dec 5, 2008·Alimentary Pharmacology & Therapeutics·E LahnerG Delle Fave
Jan 9, 2009·Journal of Clinical Microbiology·Mitsushige SugimotoDavid Y Graham
Mar 3, 2009·Helicobacter·R John DobbsJohn Williams
May 7, 2009·Journal of Neurochemistry·Xinglong WangXiongwei Zhu
May 15, 2009·Journal of Neuroimmunology·Xiuyan HuangHoward E Gendelman
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shamol SahaBenjamin Wolozin

❮ Previous
Next ❯

Citations

May 10, 2013·Bulletin of Experimental Biology and Medicine·O V KorotkovaM V Dalin
Dec 19, 2013·Nature Reviews. Gastroenterology & Hepatology·Francesco FranceschiAntonio Gasbarrini
Jul 4, 2015·Journal of Neurovirology·Alan C Jackson
Jun 21, 2012·Journal of Digestive Diseases·Huck-Joo Tan, Khean-Lee Goh
Mar 26, 2016·Parkinsonism & Related Disorders·Valeria D FeliceSiobhain M O'Mahony
Sep 16, 2011·Helicobacter·Hidekazu SuzukiAntonio Gasbarrini
Mar 19, 2014·Parkinsonism & Related Disorders·Ai Huey TanShen-Yang Lim
Jan 7, 2015·Parkinsonism & Related Disorders·Ai Huey TanShen-Yang Lim
Apr 12, 2016·British Journal of Clinical Pharmacology·Aisha D AugustinR John Dobbs
Dec 30, 2011·Neuro-degenerative Diseases·R John DobbsIngvar T Bjarnason
Oct 19, 2017·Current Neurology and Neuroscience Reports·Eamonn M M Quigley
Nov 11, 2011·The Cochrane Database of Systematic Reviews·Karen ReesYoav Ben-Shlomo
Jun 5, 2019·Journal of Movement Disorders·Han-Lin Chiang, Chin-Hsien Lin
Sep 19, 2014·World Journal of Gastroenterology : WJG·Frank WongMichael F Byrne
Oct 4, 2014·World Journal of Gastroenterology : WJG·Traci L Testerman, James Morris
Jul 12, 2020·Journal of Clinical Medicine·Rosalind M TuckerR John Dobbs
Sep 8, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Ai Huey TanAnthony E Lang
Sep 12, 2019·Annual Review of Pharmacology and Toxicology·Caitríona Long-SmithJohn F Cryan
Aug 14, 2019·Medicina·Aleksejs DerovsAngelika Krumina
Mar 5, 2016·Journal of Clinical Neurology·Gülşah Çamcı, Sıdıka Oğuz
Jun 24, 2017·Paediatric and Perinatal Epidemiology·Marianna KarachaliouSilvia de Sanjose
Apr 14, 2017·Journal of Clinical Neurology·Kandadai Rukmini MridulaTuraga Suryaprabha
Sep 27, 2019·Frontiers in Medicine·Aisha D AugustinAndré Charlett
Jul 4, 2018·Journal of Parkinson's Disease·David J McGeeElizabeth A Disbrow
Jul 6, 2019·Frontiers in Neurology·Nattakarn LimphaiboolWojciech Kozubski
Oct 8, 2020·Der Nervenarzt·M M UngerW H Oertel
Feb 27, 2021·Frontiers in Immunology·Nina GorléRoosmarijn E Vandenbroucke
Apr 17, 2021·Annals of Medicine·Elisa MenozziAnthony H V Schapira
Aug 10, 2021·Metabolic Brain Disease·Sara Ayman MoustafaMohamed Salama

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
sedation
enzyme-linked immunosorbent assay
PCR
biopsy
ELISA
electrophoresis

Software Mentioned

stata
Frontier Software PLC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.