PMID: 11319140Apr 25, 2001Paper

Differential effect of hexoses on hamster embryo development in culture

Biology of Reproduction
T E LudwigB D Bavister

Abstract

The effects of glucose, fructose, and galactose on hamster embryo development in the absence of phosphate were studied in culture. One- and two-cell embryos were cultured to the blastocyst stage in HECM-9 medium without hexose or in medium with increasing concentrations of hexoses. Embryo development, cell number, and cell allocation were assessed in blastocysts. Blastocyst viability was determined by transfer to pseudopregnant recipients. Although 0.25 mM fructose increased mean cell number, low glucose concentrations had no stimulatory effect on development to blastocyst. Both galactose and 5.0 mM glucose were detrimental to embryos. Addition of 0.5 mM glucose increased implantation and fetal viability as compared with controls. Compared with 0.5 mM glucose, treatment with 0.25 mM fructose gave similar implantation and fetal viability, whereas 5.0 mM glucose tended to decrease implantation and significantly decreased fetal development. These data demonstrate that morphology is a poor indicator of embryo viability and that exposure of preimplantation embryos to glucose or fructose is important for embryo viability post-transfer. Although no difference in blastocyst viability was detected between embryos cultured with 0.25 mM f...Continue Reading

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Citations

Feb 23, 2013·Journal of Assisted Reproduction and Genetics·Yves MénézoKay Elder
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A LarsonR M Roberts
Jul 19, 2014·Human Reproduction Update·Elpiniki Chronopoulou, Joyce C Harper
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Mar 21, 2012·Molecular Reproduction and Development·Rebecca L Krisher, Randall S Prather
Jun 22, 2005·Theriogenology·Pimprapar WongsrikeaoTakashi Nagai
Apr 9, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Young-Ho ChoiKatrin Hinrichs
Jul 8, 2014·Fertility and Sterility·Dean E MorbeckThomas Moyer
Mar 8, 2007·Molecular Reproduction and Development·M Barceló-Fimbres, G E Seidel
Mar 5, 2005·Reproduction, Fertility, and Development·Michelle Lane, David K Gardner

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