Differential effect of high dietary fat intakes on haemorheological parameters in rats

The British Journal of Nutrition
Cheng-Jeng TaiHong-Jen Liang

Abstract

High dietary intake of fats has been thought to be one of the major risk factors for the development of CVD. Less is known about the possible influence of fats from various sources on haemorheological abnormalities, which are considered an important factor in the pathogenesis of these diseases. The goal of the present study was to investigate effects of high-fat diets enriched in unsaturated fatty acids (USFA), SFA or trans-fatty acids (TFA), respectively, on haemorheological parameters in rats. Wistar female rats were divided into four groups and fed diets based on the AIN-93M formulation containing approximately 10 % energy from soyabean oil (control group) or 40 % energy from soyabean oil (USFA), palm oil (SFA) and vegetable shortening (TFA) for 8 weeks. The results showed that rats fed high-fat diets exhibited significant increases in serum TAG levels (P < 0.01), plasma viscosity (P < 0.01), whole blood viscosity (P < 0.01) and internal viscosity (P < 0.01) compared to the controls. The TFA group showed a significant decrease in erythrocyte deformability (P < 0.01) and increase in internal viscosity (P < 0.01) compared with the other groups. In addition, a significant increase in blood levels of free radicals (P < 0.01) was...Continue Reading

References

Apr 15, 1985·Thrombosis Research·P HenrikssonO Edhag
Jan 1, 1995·Annual Review of Nutrition·M B KatanR P Mensink
Jan 22, 1998·Free Radical Biology & Medicine·O K BaskurtH J Meiselman
Feb 11, 1999·Journal of the American Dietetic Association·D B AllisonJ T Heimbach
Dec 18, 2001·Journal of Clinical Apheresis·D I Bendig-PhilpottF J Strobl
Feb 13, 2002·Circulation·Rozenn N LemaitreDavid S Siscovick
Jan 1, 2003·Veterinary Research Communications·G N HerńandezM L Rasia
Mar 31, 2004·The American Journal of Clinical Nutrition·Dariush MozaffarianEric B Rimm
Mar 26, 2005·Metabolism: Clinical and Experimental·Ahamed IbrahimReddy Ghafoorunissa
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Herbert H Lipowsky
Oct 14, 2005·Seminars in Vascular Medicine·Gordon D O LoweJohn Danesh
Feb 8, 2006·Biochemical and Biophysical Research Communications·Tieqiang ZhaoGeorge Liu
Apr 20, 2006·Archives of Biochemistry and Biophysics·M M Elahi, B M Matata
Jan 17, 2007·International Journal of Laboratory Hematology·M ZandeckiA Godon
Oct 11, 2007·The British Journal of Nutrition·Kevin A HarveyRafat A Siddiqui
Mar 28, 2008·Current Hypertension Reports·Marlen Damjanovic, Matthias Barton

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