PMID: 6165279Jan 1, 1980Paper

Differential effect of human interferon on normal and neoplastic T- and B-cell lymphocytes

Annals of the New York Academy of Sciences
A M AttallahT J Yeatman

Abstract

The effect of human interferon (HIF) on the growth and function of normal and neoplastic proliferating human T and B cells was studied. Cell cycle analysis by flow-cytometry showed that up to 2000 units of HIF had little effect on the proliferating fraction (that is, the present S + G2 + M phases of the cell cycle) of normal T cells grown continuously wit growth-promoting factor from PHA-stimulated lymphocytes, while 500 units of HIF suppressed the percent S + G2 + M of the acute lymphocytic leukemia (ALL) T-cell line, MOLT, by 36%. Up to 2000 units of HIF had a moderate enhancing effect on the percent S + G2 + M of PWM-stimulated lymphocytes. In striking contrast, a single unit of HIF caused nearly 40% suppression of the percent S + G2 + M of Daudi, a Burkitt's lymphoma cell. One-thousand units of HIF did not decrease the number of antibody-forming normal cells, and up to 500 units of HIF did not inhibit the total Ig secreted by these cells. These results suggest that amounts of HIF affecting the proliferation of some neoplastic lymphoid cells has little effect on the proliferation of normal T and B cells. In addition, HIF does not appear to affect polyclonal induction of B-cell differentiation.

References

Jan 1, 1978·Advances in Experimental Medicine and Biology·M D JohnstonN B Finter
Jan 1, 1979·International Archives of Allergy and Applied Immunology·A M AttallahJ C Petricciani
Sep 18, 1977·Blut·H Strander
Dec 28, 1978·The New England Journal of Medicine·T C MeriganS A Rosenberg
Jan 1, 1979·International Archives of Allergy and Applied Immunology·A M Attallah, D M Strong
Jan 1, 1979·International Archives of Allergy and Applied Immunology·A M Attallah, T Folks
Jan 1, 1978·Advances in Experimental Medicine and Biology·S Einhorn, H Strander
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A S Fauci, K R Pratt
Feb 1, 1974·Journal of the National Cancer Institute·I GresserD Brouty-Boyé

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·A M AttallahJ C Petricciani
Jun 1, 1986·Toxicology·K P PandyaP K Ray
Jun 2, 1998·Environmental Toxicology and Pharmacology·J N Dhuley, S R Naik
May 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Tanneberger, P Hrelia
Apr 1, 1994·Pharmacology & Toxicology·P HreliaG Cantelli-Forti
Jan 1, 1982·Veterinary Immunology and Immunopathology·F KristensenS Lazáry
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E CelisR W Miller
Jan 1, 1983·AIDS Research·T V Shankey, M E Eyster
Jan 1, 1981·Microbiology and Immunology·T Kato, T Minagawa

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