Differential effect of interferon on DNA synthesis, 2-deoxyglucose uptake and ornithine decarboxylase activity in 3T3 cells stimulated by polypeptide growth factors and tumor promotors

Journal of Cellular Physiology
T SreevalsanJ Burchell

Abstract

Quiescent 3T3 cells can be stimulated to enter S by defined factors. When used in combination, three polypeptide hormones (EGF, vasopressin, and insulin), or a tumor promotor and insulin, are very effective in stimulating DNA synthesis. Like serum, the defined factors also stimulate deoxyglucose uptake and induce the synthesis of ornithine decarboxylase during G1. The second stage of deoxyglucose uptake and the induction of ornithine decarboxylase are protein synthesis-dependent events. When added with the growth factors, mouse interferon inhibits the synthesis of DNA and the induction of ornithine decarboxylase but has no effect on the uptake of deoxyglucose. Kinetic experiments comparing the effect of inhibitors of translation or transcription on induction of ornithine decarboxylase with the effect of interferon suggest that interferon may affect the synthesis of enzyme by inhibiting both transcription and translation of message. The findings provide further support for the proposition that interferon exerts a differential effect on mitogen-stimulated events events which are dependent on continuous protein synthesis.

References

Nov 1, 1977·The Journal of Cell Biology·G P Matarese, G B Rossi
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H R Bourne, E Rozengurt
Sep 1, 1977·Bacteriological Reviews·R M Friedman
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G B RossiF Belardelli
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E RozengurtP Pettican
Jan 1, 1978·Annual Review of Biochemistry·A B PardeeR F Kletzien
Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Apr 13, 1979·Biochemical and Biophysical Research Communications·T SreevalsanE Rozengurt
May 1, 1977·Experimental Cell Research·K Mierzejewski, E Rozengurt
Aug 24, 1978·Nature·F Balkwill, J Taylor-Papadimitriou
Sep 15, 1978·International Journal of Cancer. Journal International Du Cancer·F BalkwillJ Taylor-Papadimitriou
Apr 1, 1977·Journal of the National Cancer Institute·A Fuse, T Kuwata
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E Rozengurt, L A Heppel
Jan 1, 1964·Biochemical and Biophysical Research Communications·J Taylor
Feb 1, 1972·Canadian Journal of Microbiology·M V O'ShaughnessyK R Rozee
Jan 1, 1972·Advances in Cancer Research·I Gresser
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S PenmanM Penman
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M N Oxman, M J Levin

❮ Previous
Next ❯

Citations

Dec 1, 1989·Journal of Neuroscience Research·P A EcclestonR Mirsky
Jan 1, 1987·Cancer Metastasis Reviews·M Shearer, J Taylor-Papadimitriou
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P B FisherI B Weinstein
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M EinatA Kimchi
Jan 1, 1981·Journal of Interferon Research·J Taylor-PapadimitriouE Rozengurt
May 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Tanneberger, P Hrelia
Jun 4, 1988·British Medical Journal·D GalvaniJ C Cawley
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·N Dafny
Jul 1, 1984·Biochemical Pharmacology·W Lilienblum, K W Bock
May 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P Hrelia, S Tanneberger
Jul 1, 1986·Experimental Cell Research·N EbsworthJ Taylor-Papadimitriou
Mar 1, 1983·Journal of Cellular Physiology·E Butler-Gralla, H R Herschman
Aug 1, 1984·Journal of Cellular Physiology·N M EbsworthE Rozengurt
Oct 1, 1986·Journal of Cellular Physiology·A Rodriguez-Pena, E Rozengurt
Jan 15, 1986·European Journal of Biochemistry·S Vogel, J Hoppe
Dec 17, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hua TangKen-ichi Yamamura
May 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D TruebaD Ganem
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·K Tanaka, K S Chang
Jun 1, 1988·Molecular and Cellular Biology·A S MasibayT Sreevalsan
Feb 1, 1983·Journal of Virology·E J Lee, T Sreevalsan
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli
May 1, 1991·Molecular and Cellular Endocrinology·G Scalabrino, E C Lorenzini
Mar 29, 1985·Biochemical and Biophysical Research Communications·E VicenziP Ghezzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.