Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study.

Lipids in Health and Disease
Katerina A MarinouIsmene A Dontas

Abstract

Lipid-enriched diets and oxidative stress are risk factors for the development of atherosclerosis. The effects of the methanolic (ME) and cyclohexane (CHE) extracts of the Pistacia vera nut, often included in the Mediterranean diet, were studied in the rabbit model of atherosclerosis. Twenty-four New Zealand White rabbits received atherogenic diet (Control Group), supplemented with ME (Group ME) or CHE (Group CHE) for 3 months. Previously, a GC-MS and a UHPLC LC-DAD-ESI(-)-HRMS/MS method were developed to investigate the extracts' chemical profiles. Blood samples at baseline and monthly determined lipid profile, lipid peroxidation and liver function. The aorta, myocardium and liver were examined histologically at 3 months.Groups ME and CHE had significantly higher HDL- and non-significantly lower LDL-cholesterol median % changes from baseline than the Control Group. Triacylglycerol was significantly higher in Group CHE vs. Control. MDA values were significantly lower in Group ME vs. Control and CHE. ALT and AST were significantly higher in Group CHE vs. Control. gamma-GT was lower in Group ME vs. Control. Aortic intimal thickness was significantly less in Groups ME and CHE vs. Control; Group ME atherosclerotic lesions were sign...Continue Reading

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Citations

Aug 16, 2011·Lipids in Health and Disease·Ismene A DontasTheodore Karatzas
Aug 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ji Young ParkMan Hee Rhee
May 12, 2012·Asian Pacific Journal of Tropical Medicine·Oluwatosin AdaramoyeMoosavi-Movahedi Ali
Jan 13, 2015·Experimental Gerontology·Fidele NtchapdaThéophile Dimo
Jul 14, 2016·Journal of Food Science and Technology·Marcela Lilian MartínezGabriela Egly Feresin
Jan 31, 2021·Metabolites·Georgios TheodoridisOn Behalf Of The FoodOmicsGR Ri Consortium

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