Differential effect of platelets on plasminogen activation by tissue plasminogen activator, urokinase, and streptokinase

Thrombosis Research
S W GaoM A Shuman

Abstract

In this report, we have examined the effects of platelets on plasminogen activation by different activators. Platelets enhance activation of plasminogen by both 1- and 2-chain tissue plasminogen activator (t-PA). The primary effect of platelets is to lower the Km with a corresponding 5-8-fold increase in the kcat/Km. The effect is saturable with respect to the platelet concentration. Platelets enhance activation of both glu- and lys-plasminogen by t-PA. Platelets have no effect on plasminogen activation by streptokinase, and high and low molecular weight urokinase. Thus, there are marked differences in the effects of platelets on plasminogen activation depending on the plasminogen activator. These differences are likely to reflect differences in the interaction between platelets and the plasminogen activators.

References

Jun 1, 1987·The Journal of Clinical Investigation·J Loscalzo, D E Vaughan
Jun 1, 1986·The Journal of Clinical Investigation·L A MilesE F Plow
Dec 1, 1987·The Journal of Clinical Investigation·K A HajjarR L Nachman
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L A EricksonD J Loskutoff
Jan 1, 1974·Methods in Enzymology·N L Baenziger, P W Majerus
Jul 1, 1973·The Journal of Clinical Investigation·S NiewiarowskiP Gillies
Jan 1, 1974·Methods in Enzymology·B A ChibberE T Mertz
Oct 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·S M CamioloT Astrup

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Citations

Nov 17, 1992·Biochimica Et Biophysica Acta·M ShimokawaT Kinoshita
Dec 2, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·E F Plow, L A Miles
Nov 9, 2000·Molecular and Biochemical Parasitology·L AvilanA M Rodriguez
Jan 22, 2004·Critical Reviews in Oncology/hematology·Indra Ramasamy
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A YarzábalI Kansau
Sep 12, 2000·Current Cardiology Reports·I Conde-Pozzi, N Kleiman
Jan 29, 2020·Platelets·Paul VulliamyMatthew D Neal
Jan 1, 1991·Platelets·B Pasche, J Loscalzo
Sep 1, 1991·Progress in Cardiovascular Diseases·J HenkinH C Yang

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