Differential effect of thalamic and cortical lesions on memory systems in the rat

Behavioural Brain Research
T Alexinsky

Abstract

The behavioral effects of lesions of anterior thalamic and medio-dorsal thalamic nuclei, posterior cingulate (retrosplenial) and posterior parietal associative cortex were studied in rats performing a eight-arm radial maze, in which three/eight arms were baited. Lesions were made after rats reached a training criterion. Rats were tested 2 weeks later, in the same experimental apparatus. In the first experiment, performance was assessed by number of errors and time per trial, retention by comparing performance during training with retraining sessions (using specific scores for reference and working memory) and by an evaluation of the 'reminiscence' defined as daily improvement in performance. After the reacquisition of the task, the rats were tested in experiment II, in modified situations for an evaluation of flexible aspects of memory processing in this spatial task. Results showed dissociation between the effects of the different lesions, according to the specific demands of the different tasks. Posterior parietal lesions produced significant, but relatively mild deficits, in all situations, in accordance with the well-established function of this cortical region in spatial tasks. In contrast, after cortical lesion in the ret...Continue Reading

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Citations

Sep 11, 2008·Journal of Molecular Neuroscience : MN·Nobuyoshi Hagino
Dec 17, 2003·Behavioral Neuroscience·James P Moran, John C Dalrymple-Alford
Jan 28, 2005·The European Journal of Neuroscience·Etienne SaveBruno Poucet
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Mar 1, 2011·Behavioural Brain Research·Farzaneh Ghiafeh DavoodiBehzadi Jila
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Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Mathieu WolffEtienne Coutureau
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May 11, 2013·Behavioural Brain Research·Magdalena Mendez-LopezMathieu Wolff
Jun 9, 2016·Neurobiology of Learning and Memory·Benjamin J Clark, Ryan E Harvey
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