Differential effects of 3-isobutyl-1-methylxanthine injected intrathecally or intracerebroventricularly on antinociception induced by opioids administered intracerebroventricularly in the mouse

Neuropeptides
H W SuhY H Kim

Abstract

Various doses of 3-isobutyl-1-methylxanthine (IBMX), a cAMP phosphodiesterase inhibitor, injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) alone did not show any antinociceptive effect. IBMX (0.01 to 1 ng) pretreatment i.t. for 10 min dose-dependently attenuated the inhibition of the tail-flick response induced by i.c.v. administered morphine (2 micrograms), beta-endorphin (1 microgram), and U50, 488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl] benzeocetamide), 60 micrograms. However, pretreatment with IBMX i.c.v. did not affect the inhibition of the tail-flick response induced by morphine, beta-endorphin, and U50, 488H administered i.c.v. Neither i.c.v. nor i.t. pretreatment with IBMX attenuated the inhibition of the tail-flick response induced by D-Pen2-D-Pen5-enkephalin (DPDPE; 10 micrograms) administered i.c.v. Our results suggest that spinal but not supraspinal cAMP phosphodiesterases are involved in mediating antinociception induced by morphine, beta-endorphin and U50, 488H administered supraspinally. However, neither spinal nor supraspinal cAMP phosphodiesterase is involved in mediating antinociception induced by DPDPE administered supraspinally.

References

Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·D NicholsonJ Sawynok
Sep 1, 1989·European Journal of Pharmacology·H H SuhL L Tseng
Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox

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Citations

Jul 31, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ki M ChungHong W Suh
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Lindsay B Hough, Frank L Rice
Jun 28, 2016·Pharmacological Reviews·Louis GendronGraciela Pineyro
May 21, 2003·The Journal of Pharmacology and Experimental Therapeutics·Willias MasochaJosé M Baeyens

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