Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice

Progress in Neuro-psychopharmacology & Biological Psychiatry
Eric S Landry, Pierre A Guertin

Abstract

The effects induced by serotonergic (5-HT) agonists of the 5-HT1 and 5-HT2 subclasses were examined on hindlimb movement generation in adult mice completely spinal cord transected at the low thoracic level. One week postspinalization, intraperitoneal injection (0.5-10 mg/kg) of meta-chlorophenylpiperazine (m-CPP; 5-HT(2B/2C) agonist) or trifluoromethylpiperazine (TFMPP; 5-HT(1B) agonist) failed to induce locomotor-like movements. However, dose-dependent nonlocomotor movements were induced in air-stepping condition or on a motor-driven treadmill. In contrast, hindlimb locomotor-like movements were found after the injection of quipazine (5-HT(2A/2C) agonist; 1-2 mg/kg). Combined with L-DOPA (50 mg/kg, i.p.), low doses of quipazine but not of m-CPP and TFMPP produced locomotor-like and nonlocomotor movements in air-stepping condition or on the treadmill. Subsequent administration of m-CPP or TFMPP significantly reduced and often completely abolished the hindlimb movements induced by quipazine and L-DOPA. Altogether, these results demonstrate that 5-HT(2A/2C) receptor agonists promote locomotion while 5-HT(1B) and 5-HT(2B/2C) receptor agonists interfere with locomotor genesis in the hindlimbs of complete paraplegic mice. These resu...Continue Reading

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Citations

Mar 23, 2007·Journal of Neurotrauma·Pascal RouleauPierre A Guertin
Jul 15, 2011·Brain : a Journal of Neurology·Linard FilliMartin E Schwab
Apr 29, 2011·Journal of Visualized Experiments : JoVE·Christopher K ThompsonT George Hornby
Feb 22, 2012·The Journal of Physiology·Urszula SławińskaLarry M Jordan
Jan 23, 2016·Behavioural Brain Research·Hillary E SwannMichele R Brumley
Dec 15, 2015·Physiology & Behavior·Valerie Mendez-GallardoMichele R Brumley
Sep 2, 2009·Brain Research Reviews·Pierre A Guertin
Mar 28, 2009·Journal of Neuroscience Research·Pierre A Guertin, Inge Steuer
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Guadalupe BravoEnrique Hong
Apr 20, 2011·The European Journal of Neuroscience·E PearlsteinL Vinay
Feb 25, 2015·Frontiers in Neural Circuits·Mousumi Ghosh, Damien D Pearse
May 29, 2014·Journal of Neural Transmission·Raffaele NardoneEugen Trinka
Jul 29, 2005·Journal of Neurophysiology·Pierre A Guertin, Inge Steuer
Aug 14, 2009·Journal of Neurophysiology·Antonny CzarneckiJürg Streit
Apr 4, 2019·Journal of Neurophysiology·Yury GerasimenkoPrithvi K Shah
Feb 7, 2006·Médecine sciences : M/S·Nicolas P Lapointe, Pierre A Guertin
Feb 18, 2021·Behavioural Pharmacology·Hillary E Swann-ThomsenMichele R Brumley
Aug 20, 2021·The Journal of Physiology·Marie BoulainLaurent Juvin

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