Differential effects of a luteinizing-hormone-releasing hormone (LHRH) antagonist analogue on lordosis behavior induced by LHRH and the LHRH fragment Ac-LHRH5-10

Neuroendocrinology
R L Moss, C A Dudley

Abstract

Both the luteinizing-hormone-releasing hormone (LHRH) decapeptide and an LHRH fragment consisting of the last 6 amino acids of the decapeptide, Ac-LHRH, have been shown to enhance lordosis behavior in ovariectomized, estradiol-benzoate treated female rats. Although the behavioral efficacy of the 2 peptides is similar, several lines of research suggest that the fragment and the decapeptide may act via different mechanisms. The present study attempted to differentiate the behavioral action of the 2 peptides by administering a long-acting LHRH antagonist analogue prior to infusion of either Ac-LHRH or LHRH. Without antagonist administration, the decapeptide and the fragment were equally effective in elevating lordotic posturing 90 min after bilateral infusion through cannulae positioned in the ventromedial nucleus of the hypothalamus (VMH). Infusion of a potent LHRH antagonist analogue [Ac-dehydro, Pro, pCl, D-Phe, DTrp]-LHRH, into the VMH significantly reduced the lordosis-to-mount ratio in animals subsequently treated with the LHRH decapeptide, but had no significant effect on lordotic behavior when the animals were subsequently infused with the Ac-LHRH fragment. The results indicate that LHRH enhancement of mating behavior is a...Continue Reading

Citations

Dec 1, 1991·Physiology & Behavior·C A Dudley, R L Moss
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S MoraG Díaz-Véliz
Oct 1, 1991·Trends in Neurosciences·I Reisert, C Pilgrim
Oct 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M Meredith
Apr 1, 1992·Journal of Neuroendocrinology·A C LawrenceD J Campbell
Aug 3, 2001·General and Comparative Endocrinology·P A Schiml-WebbE F Rissman
Jun 1, 1991·Molecular and Cellular Neurosciences·T L Thompson, R L Moss
Jul 22, 2004·Behavioural Brain Research·Mary S ErskineEva K Polston

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