PMID: 21541506Aug 1, 1996Paper

Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation

International Journal of Oncology
H MiyazakiK Furukawa

Abstract

A murine monoclonal antibody, S2-566, was generated by immunization with a melanoma line, SK-MEL-28. Although AbS2-566 showed a similar reaction pattern with that of anti-GD3 mAbR24 in cell surface serology, it recognized a disialyl galactosyl structure not only in GD3 but in GT1a and GQ1b. The suppression of the growth of cultured melanoma cells by AbS2-566 was not obvious, in contrast with AbR24. However, the mitogenic effects of AbS2-566 on peripheral lymphocytes were observed showing similar kinetics to those of mAbR24, suggesting different signaling effects based on the different epitope structures.

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