PMID: 9431578Feb 12, 1998Paper

Differential effects of acrylamide on the degeneration and regeneration of myelinated fibers between C57BL/Ola and C57BL/6J mice after crush injury

Journal of UOEH
H Qiu-YueY Murai

Abstract

To investigate differences in the pathologic processes between mutant C57BL/Ola (Ola) and normal C57BL/6J (6J) mice, the effect of acrylamide (ACR) on the degeneration and regeneration of myelinated fibers after crushing the sciatic nerve was morphometrically evaluated. Both Ola and 6J mice were treated with either ACR (subcutaneous injection of 50 mg/kg every other day for 13 days, n = 6) or physiological saline (n = 6). Morphometric evaluation of myelinated fibers of the sciatic nerve 5 mm distal to the proximal end of the crush site was performed systematically on day 14 of the crushing for each mouse. In Ola mice treated with either saline or ACR, large and small myelinated fibers remained without obvious progression of Wallerian degeneration, and degeneration of myelinated fibers was slower than in 6J mice. On the other hand, in 6J mice treated with either saline or ACR, many small myelinated fibers regenerated after degeneration and loss of both large and small myelinated fibers. In Ola mice, no statistically significant difference in the morphometric parameters was found between saline-treated and ACR-treated groups. Therefore, ACR did not have a significant effect on Wallerian degeneration of myelinated fibers in Ola mi...Continue Reading

Citations

Jun 12, 2019·Toxicologic Pathology·Bernard S Jortner

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