Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats

Brain Research
Jerry P PianCindy L Ehlers

Abstract

Age-related developmental differences in sensitivity to the acute effects of alcohol may play an important role in the development of alcoholism. The present study was designed to evaluate the acute effects of alcohol on cortical electroencephalogram (EEG) in adolescent (P36) and adult (P78) Wistar rats. Five minutes of EEG was recorded after administration of 0, 0.75 or 1.5 g/kg alcohol. The righting reflex was performed to measure the sedative effects of alcohol (3.5 g/kg) and total sleeping time for each rat. Our results showed that alcohol (1.5 g/kg) increased power in the 1-2 Hz band and decreased the power in the 32-50 Hz band in the parietal cortical region of adolescent rats. Alcohol (1.5 g/kg) also increased stability of the EEG power in the slow-wave frequency bands (2-4 Hz, 4-6 Hz, and 6-8 Hz) of adolescent rats. In the frontal cortex of adult rats, but not in adolescent rats, alcohol (1.5 or 0.75 g/kg) decreased the power in the 16-32 Hz frequency band. Alcohol (1.5 g/kg) differentially increased power in a multiple of slow-wave frequency bands (2-4 Hz and 4-6 Hz) in the parietal cortex of adult rats as compared to adolescent rats. Adolescent rats were shown significantly shorter sleeping time and higher blood alcoh...Continue Reading

References

Mar 1, 1976·Journal of Studies on Alcohol·A J ErnstL Nakano
Oct 1, 1979·The Journal of Pharmacy and Pharmacology·S J Grieve, J M Littleton
Aug 1, 1992·Physiology & Behavior·H Merica, J M Gaillard
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S LidowP Rakic
Jan 1, 1991·Psychopharmacology·C L Ehlers, R I Chaplin
Feb 1, 1988·Electroencephalography and Clinical Neurophysiology·T GasserL Sroka
Sep 1, 1989·Electroencephalography and Clinical Neurophysiology·C L EhlersM A Schuckit
Jan 1, 1985·Neurobiology of Aging·R E DustmanJ M Talone
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1981·Electroencephalography and Clinical Neurophysiology·B E HetzlerG Griffin
Oct 10, 1980·Science·D Purves, J W Lichtman
Sep 1, 1993·Progress in Neurobiology·R E DustmanR Y Emmerson
Aug 1, 1993·Alcoholism, Clinical and Experimental Research·J L York, A W Chan
Mar 1, 1996·Archives of General Psychiatry·M A Schuckit, T L Smith
Jan 1, 1996·Electroencephalography and Clinical Neurophysiology·W M KanekoC L Ehlers
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·P J LittleH S Swartzwelder
Jun 1, 1997·Biological cybernetics·E BaşarC Başar-Eroglu
Oct 23, 1997·The Journal of Comparative Neurology·P R Huttenlocher, A S Dabholkar
May 20, 1998·Alcohol·H S SwartzwelderP J Little
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
Oct 13, 1998·Psychopharmacology·A C GrobinA L Morrow
Oct 13, 1998·Psychopharmacology·C L EhlersD Cloutier
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·S S MoyG R Breese
Apr 21, 1999·Brain Research. Brain Research Reviews·A K Mehta, M K Ticku
Jun 1, 1999·JAMA : the Journal of the American Medical Association·M A Schuckit
Jul 16, 1999·Neurochemistry International·S J Mihic
Jul 16, 1999·Neurochemistry International·D M Lovinger
Jul 22, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C J SlaweckiC L Ehlers
Aug 12, 1999·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
Aug 24, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R E DustmanR Y Emmerson
Feb 19, 2000·Alcohol·M M Silveri, L P Spear
Jun 27, 2000·Psychopharmacology·C J SlaweckiC L Ehlers
May 18, 2001·Brain Research. Developmental Brain Research·C J SlaweckiC L Ehlers
May 24, 2001·Alcoholism, Clinical and Experimental Research·C L EhlersE Phillips
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Craig J Slawecki
May 1, 2002·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Tamara L DoremusLinda Patia Spear
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Qiang LiH S Swartzwelder

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Citations

Dec 15, 2010·Cerebral Cortex·Hank P JedemaCharles W Bradberry
Feb 13, 2010·Addiction Biology·John C CrabbeCindy L Ehlers
May 3, 2014·Pharmacology, Biochemistry, and Behavior·Anita DesikanCindy L Ehlers
Aug 28, 2012·European Journal of Pediatrics·Mara WurdakJörg Wolstein
Aug 25, 2009·Pharmacology, Biochemistry, and Behavior·Jerry P PianCindy L Ehlers
Oct 23, 2008·Pharmacology, Biochemistry, and Behavior·Brendan M Walker, Cindy L Ehlers
Oct 17, 2008·Alcohol·José R CriadoCindy L Ehlers
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Jerry P PianCindy L Ehlers
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Candice E Van SkikeDouglas B Matthews
May 13, 2014·Neuroscience and Biobehavioral Reviews·Linda Patia Spear, H Scott Swartzwelder
Apr 2, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·James R Roberts, Denis Dollard
Feb 4, 2014·Alcoholism, Clinical and Experimental Research·Cindy L EhlersDerek N Wills
Mar 9, 2021·Brain Plasticity·Ibdanelo CortezJ Leigh Leasure

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