Differential effects of acute cocaine and placebo administration on visual cortical activation in healthy subjects measured using BOLD fMRI.

Pharmacology, Biochemistry, and Behavior
Steven B LowenJ M Levin

Abstract

Many blood oxygenation level dependent (BOLD) functional magnetic resonance imaging studies have shown a strong response due to cocaine in brain regions with high concentrations of dopamine receptors. However, cocaine also has non-specific effects, including cardiovascular changes that may cause changes in BOLD signals, raising the possibility that measured changes could be due to these non-specific effects. The following experiment was conducted to address this concern. Subjects were given either cocaine or saline infusions during a long BOLD functional magnetic resonance imaging study. A flashing uniform-field stimulus, periodically alternating between on and off, provided a strong activation of primary visual cortex. There was a significant main effect of drug between cocaine and placebo. Although we did not demonstrate a significant drug x time interaction, BOLD signal changes associated with visual stimulation appeared unchanged after cocaine administration, whereas the signal differences appeared to decrease during placebo. Explanation of the differential response between the two groups may reflect cocaine expectancy instead of a direct effect of cocaine on BOLD signal changes but will require further investigation to ful...Continue Reading

References

Mar 1, 1995·Drug and Alcohol Dependence·R W FoltinF R Levin
Jul 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·G M HathoutR M Harper
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H R HeekerenA Villringer
Oct 23, 1997·Neuron·H C BreiterS E Hyman
Jan 22, 1998·Magnetic Resonance Imaging·A M HowsemanR Turner
Feb 12, 1998·JAMA : the Journal of the American Medical Association·M J KaufmanP F Renshaw
Apr 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B JohnsonL Kramer
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ChenK Ugurbil
Jul 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R L GollubR Weisskoff
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Dec 1, 2001·Journal of Substance Abuse Treatment·C A Dackis, C P O'Brien
Jan 5, 2002·NeuroImage·Todd A MulderinkTodd B Parrish
May 30, 2002·Magnetic Resonance Imaging·Leslie K JacobsenJohn H Krystal
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng LuoShi-Jiang Li
Aug 6, 2003·Life Sciences·Jing-Huei LeeNora D Volkow
Dec 14, 2004·NeuroImage·Thomas T LiuRichard B Buxton
Aug 23, 2005·Pharmacology, Biochemistry, and Behavior·Thomas F NewtonLiam Nestor
Feb 4, 2006·Human Brain Mapping·Tom JohnstoneTerrence R Oakes
Apr 26, 2006·NeuroImage·Rebecca SaxeNancy Kanwisher

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Citations

Dec 25, 2010·Human Brain Mapping·Marko WilkeIngeborg Krägeloh-Mann
Jun 7, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stephanie C LicataScott E Lukas
Sep 25, 2014·Frontiers in Human Neuroscience·Jacob LahrStefan Klöppel

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