Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years.

Psychological Medicine
B FagerlundBirte Yding Glenthøj

Abstract

The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition. The aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- and sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult- or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates. There was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit seq...Continue Reading

References

Jun 1, 1990·Archives of General Psychiatry·J K WingN Sartorius
Jan 1, 1988·Schizophrenia Bulletin·M J Harris, D V Jeste
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Nov 5, 1999·European Child & Adolescent Psychiatry·C Eggers
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·P M ThompsonJ L Rapoport
May 20, 2003·Journal of Clinical and Experimental Neuropsychology·Cinzia R De LucaChristos Pantelis
Jul 23, 2003·The Australian and New Zealand Journal of Psychiatry·Christos PantelisDennis Velakoulis
Nov 25, 2003·Schizophrenia Research·Eugenia KravaritiSophia Frangou
Sep 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Annamari Tuulio-HenrikssonJouko Lönnqvist
Jun 29, 2005·Schizophrenia Research·Stefan LeuchtRolf R Engel
Jul 19, 2005·Biological Psychiatry·Joseph P RhinewineSanjiv Kumra
Nov 23, 2005·Schizophrenia Research·G K MurrayM Isohanni
Feb 18, 2006·Journal of Clinical and Experimental Neuropsychology·Richard S E KeefePhilip D Harvey
Apr 11, 2006·European Child & Adolescent Psychiatry·Parthasarathy BiswasNitin Gupta
May 23, 2008·Schizophrenia Research·Richard S E KeefeKirsten Hawkins
Oct 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·T K RajjiB H Mulsant
Jan 6, 2010·The American Journal of Psychiatry·Abraham ReichenbergTerrie E Moffitt
Mar 5, 2010·Acta Psychiatrica Scandinavica·I V VahiaDilip V Jeste
Apr 21, 2011·Schizophrenia Bulletin·Nitin GogtayChristos Pantelis
Jul 19, 2011·Schizophrenia Research·Golam M KhandakerPeter B Jones
Mar 16, 2012·Biological Psychiatry·Mette Ødegaard NielsenBirte Glenthøj
Nov 23, 2012·Schizophrenia Bulletin·Robert B ZipurskyRobin M Murray
Jun 19, 2013·Journal of Cognitive Neuroscience·Christian K TamnesAnders M Fjell
Sep 10, 2013·Child and Adolescent Psychiatric Clinics of North America·Sophia Frangou
Oct 16, 2013·Schizophrenia Bulletin·Nikolaos KoutsoulerisEva Meisenzahl
Mar 13, 2014·Current Opinion in Psychiatry·Jeanne E MaglioneDilip V Jeste
May 9, 2014·JAMA Psychiatry·Carsten Bøcker PedersenWilliam W Eaton
Jun 7, 2014·Developmental Neuroscience·Christian K TamnesAnders M Fjell
Nov 13, 2015·Journal of Experimental Child Psychology·Amy S FinnJohn D E Gabrieli
May 3, 2016·Journal of Child and Adolescent Psychopharmacology·Marie Stentebjerg-OlesenPia Jeppesen
Jan 20, 2017·The Journal of Clinical Psychiatry·Karsten G JensenAnne Katrine Pagsberg
May 17, 2017·Schizophrenia Research·Philip D Harvey, Jennifer B Rosenthal
Sep 5, 2017·Neuroscience and Biobehavioral Reviews·Lies Van AsscheMathieu Vandenbulcke

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Jul 19, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·TianHong ZhangJiJun Wang

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