Differential effects of all-trans retinoic acid on the growth of human keratinocytes and mouth carcinoma epidermoid cultures. Involvement of GRIM-19 and complex I of the respiratory chain

International Journal of Immunopathology and Pharmacology
F PapaS Scacco

Abstract

Squamous cell carcinoma (SSC) is the most frequent malignant tumor of the oral cavity. A study on the effect of all-trans retinoic acid (RA) on cell growth, expression of GRIM-19 and content and activity of complex I of the mitochondrial respiratory chain in normal human keratinocytes (NHEK) and mouth carcinoma cells with low (HN) and high (KB) transformation grade was carried out. In NHEK cells, RA treatment resulted in growth suppression, significant overexpression of GRIM-19 protein, enhanced content of complex I but depressed activity of NADH-UQ oxidoreductase activity of the complex. In HN cells, RA treatment depressed cell growth, inhibited the enzymatic activity of complex I but had no significant effect on the levels of GRIM-19 and complex I. In KB cells RA had no effect on cell growth, GRIM-19 expression, content and activity of complex I.

References

Dec 11, 1986·The New England Journal of Medicine·W K HongC Vaughan
Nov 15, 1974·Life Sciences·P A Srere
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Dec 1, 1994·Current Opinion in Cell Biology·J M Love, L J Gudas
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·G FenteanyS L Schreiber
Nov 13, 1999·Nature Cell Biology·H SutterlütyW Krek
Oct 18, 2000·Free Radical Biology & Medicine·E Cadenas, K J Davies
Oct 29, 2002·Journal of Lipid Research·James E Balmer, Rune Blomhoff
Feb 13, 2003·International Journal of Immunopathology and Pharmacology·M G AlexandrakisT C Theoharides
Jul 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jun ZhangDhananjaya V Kalvakolanu
Apr 28, 2004·Cytokine & Growth Factor Reviews·Dhananjaya V Kalvakolanu
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Aug 6, 2005·The Journal of Steroid Biochemistry and Molecular Biology·J E Balmer, R Blomhoff
Sep 17, 2005·International Journal of Immunopathology and Pharmacology·C GasparettoG Ricevuti

❮ Previous
Next ❯

Citations

Nov 12, 2009·Journal of Bioenergetics and Biomembranes·Sergio PapaClaudia Piccoli
Aug 1, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying ZhouBin Ling
May 5, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying ZhouWeihua Xiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The Journal of Investigative Dermatology
Gaelle BellemèreThierry Oddos
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Tong ShenQi-xing Zhu
© 2021 Meta ULC. All rights reserved