Abstract
Apart from modulation of tumor-cell drug sensitivity, induction of differentiation might be an alternative in the treatment of tumors resistant to cytotoxic drugs. In this report the capacity to induce differentiation and to modulate the cis-diamminedichloroplatinum(II) (CDDP) sensitivity of all-trans-retinoic acid (RA), docosahexaenoic acid (DCHA), and hexadecylphosphocholine (HePC) is examined in human germ-cell tumor cell lines. In the embryonal carcinoma cell line Tera-2 and its 3.7-fold CDDP-resistant subline Tera2-CP, we evaluated the effects of 96 h of pretreatment with RA (0.1 microM), DCHA (23 microM), and HePC (25 microM) on differentiation induction and on CDDP-induced cytotoxicity, DNA platination (4-h incubation), and apoptosis (continuous incubation). Without drug treatment, Tera2-CP showed less apoptosis than Tera-2. Pretreatment with RA decreased the cytotoxicity and apoptosis induced by CDDP without resulting in decreased DNA platination and increased differentiation in both cell lines. DCHA enhanced CDDP-induced cytotoxicity and apoptosis and did not affect the embryonal character of either cell line. HePC did not affect CDDP cytotoxicity or differentiation in either cell lines. Effects of the modulators on di...Continue Reading
Citations
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Formelli, L Cleris
Oct 1, 2013·Expert Reviews in Molecular Medicine·R KosterS de Jong
Apr 22, 2011·Cell Death & Disease·R KosterS de Jong
Mar 2, 2005·Nature Reviews. Cancer·J Wolter Oosterhuis, Leendert H J Looijenga
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P Bougnoux
Sep 3, 2010·The Journal of Clinical Investigation·Roelof KosterSteven de Jong
Jan 30, 2014·PloS One·Paolo B Abada, Stephen B Howell
Aug 2, 2012·Cancer Treatment Reviews·Nawale Hajjaji, Philippe Bougnoux
Dec 11, 2002·Chest Surgery Clinics of North America·Jane Houldsworth
Dec 11, 2002·Chest Surgery Clinics of North America·Alessia C Donadio, George J Bosl
Jan 24, 2009·Urologic Oncology·Hans U SchmelzMichael Abend
May 8, 2007·Urology·Nikolay D DimovXiming J Yang
May 20, 2003·The Journal of Pathology·Diana C J SpieringsSteven de Jong
Dec 30, 2014·Andrology·C Jacobsen, F Honecker
Jan 5, 2002·Biochimica Et Biophysica Acta·R A SiddiquiW Stillwell
May 9, 2001·Biochimica Et Biophysica Acta·R A SiddiquiW Stillwell
Jun 11, 2016·Expert Opinion on Investigational Drugs·Christoph OingCarsten Bokemeyer
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jane HouldsworthR S K Chaganti
Dec 11, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F SelleJ P Lotz
Oct 20, 2019·Cancers·Ugo De GiorgiGiorgia Mangili
Sep 28, 2018·Current Oncology Reports·Silvia SchmidtovaLucia Kucerova
Sep 25, 2012·Cancer Research·Yu-Chih WuYen-Hua Huang
Dec 23, 2020·Journal of Ethnopharmacology·Ye-Ting ZouSong-Lin Li