Differential effects of alpha-beta-methylene ATP on responses to nerve stimulation in SHR and WKY tail arteries

Naunyn-Schmiedeberg's Archives of Pharmacology
M VidalS Z Langer

Abstract

The effects of alpha,beta-,methylene-adenosine triphosphate, (alpha,beta-methylene ATP, a P2-receptor desensitising agent) have been evaluated on vasoconstrictor responses elicited by exogenous agonists or electrical field stimulation in isolated perfused SHR or WKY tail arteries and on tritium release elicited by electrical field stimulation in SHR-tail arteries pre-labeled with 3H-noradrenaline. Exposure to alpha,beta-methylene ATP (0.1 mumol/l) significantly inhibited vasoconstrictor responses to electrical field stimulation in SHR tail arteries. These inhibitory effects were not further increased at a higher concentration of alpha,beta-methylene ATP (1 mumol/l). In WKY tail arteries, alpha,beta-methylene ATP (1 mumol/l) failed to significantly inhibit vasoconstrictor responses to electrical stimulation. In SHR tail arteries prelabelled with 3H-noradrenaline, alpha,beta-methylene ATP (1 mumol/l) did not inhibit the stimulation evoked release of tritium. However, at this concentration, alpha,beta-methylene ATP significantly antagonized the vasoconstrictor responses of SHR tail arteries induced by exogenous ATP (1 mumol/l), beta,gamma-methylene ATP (30 mumol/l), a stable agonist at P2-receptors, or 60 mmol/l KCl. These effects...Continue Reading

References

Oct 15, 1979·European Journal of Pharmacology·M A Luchelli-FortisS Z Langer
Jan 1, 1985·Clinical Science·G Burnstock, P Sneddon
Apr 1, 1982·The Journal of Physiology·A G BlakeleyS A Petersen
Oct 15, 1984·European Journal of Pharmacology·P SneddonG Burnstock
Oct 30, 1984·European Journal of Pharmacology·P Sneddon, G Burnstock
Aug 1, 1984·Canadian Journal of Physiology and Pharmacology·D W Cheung
Jan 5, 1981·European Journal of Pharmacology·J S FedanD P Westfall
Aug 1, 1976·Neuroscience·G Burnstock

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Citations

Apr 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·P IllesB Bucher
Apr 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·H LindL Edvinsson
Mar 28, 2008·Purinergic Signalling·David Erlinge, Geoffrey Burnstock
Dec 1, 1994·British Journal of Plastic Surgery·G Burnstock, V Ralevic
Jan 1, 1988·Pharmacology & Therapeutics·T D White
Jul 1, 1990·Journal of the Autonomic Nervous System·G Burnstock
Jan 1, 1990·Neurochemistry International·G Burnstock
Oct 1, 1993·Neurochemistry International·P Bach-y-Rita
Mar 23, 2010·Asian Journal of Andrology·Serap GurWayne J G Hellstrom
Mar 27, 2003·Autonomic & Autacoid Pharmacology·D-Y LimD-G Park
Feb 1, 1994·Journal of Autonomic Pharmacology·G Burnstock
Dec 1, 1996·Journal of Autonomic Pharmacology·G Burnstock
Jan 1, 1990·Annals of the New York Academy of Sciences·S Z Langer, S Arbilla
Nov 29, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Juliano Quintella Dantas RodriguesAron Jurkiewicz
Oct 1, 1995·Pflügers Archiv : European journal of physiology·J A Brock, D F Van Helden
Feb 1, 2003·Acta Physiologica Scandinavica·O TarasovaH Nilsson
Feb 21, 2006·Trends in Pharmacological Sciences·Geoffrey Burnstock
Jun 9, 2016·Autonomic Neuroscience : Basic & Clinical·Geoffrey Burnstock, Andrzej Loesch
Oct 15, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G Burnstock
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Geoffrey Burnstock
Jul 2, 2009·Autonomic & Autacoid Pharmacology·G Burnstock
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
May 18, 2011·The Journal of Physiology·Rebecca E Haddock, Caryl E Hill
Jan 13, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Geoffrey Burnstock

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