Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability

The European Journal of Neuroscience
Masuo OhnoJ F Disterhoft

Abstract

Alpha-calcium/calmodulin-dependent kinase II (alphaCaMKII) is central to synaptic plasticity but it remains unclear whether this kinase contributes to neuronal excitability changes, which are a cellular correlate of learning. Using knock-in mice with a targeted T286A mutation that prevents the autophosphorylation of alphaCaMKII (alphaCaMKII(T286A)), we studied the role of alphaCaMKII signaling in regulating hippocampal neuronal excitability during hippocampus-dependent spatial learning in the Morris water maze. Wild-type control mice showed increased excitability of CA1 pyramidal neurons, as assessed by a reduction in the postburst afterhyperpolarization (AHP), after spatial training in the water maze. Importantly, wild-type mice did not show AHP changes when they were exposed to the water maze without the escape platform and swam the same amount of time as the trained mice (swim controls), thus manifesting learning-specific increases in hippocampal CA1 excitability associated with spatial training. Meanwhile, alphaCaMKII(T286A) mice showed impairments in spatial learning but exhibited reduced levels of AHP that were similar to wild-type controls after water-maze training. Notably, both trained and swim-control groups of alphaC...Continue Reading

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J F DisterhoftD L Alkon
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Nov 20, 2001·Nature Neuroscience·M OhnoA J Silva
May 8, 2002·Nature Reviews. Neuroscience·J LismanH Cline
Oct 10, 2002·The European Journal of Neuroscience·Yaron SeroussiEdi Barkai
Jun 20, 2003·Journal of Neurophysiology·M Matthew OhJohn F Disterhoft
Jun 26, 2003·The European Journal of Neuroscience·Drorit Saar, Edi Barkai
Nov 5, 2003·Nature Reviews. Neuroscience·Wei Zhang, David J Linden
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarina M RodriguesGlenn E Schafe
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew W VargaJ David Sweatt
Oct 1, 2004·American Journal of Physiology. Cell Physiology·Gerard P SergeantSang Don Koh
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ype ElgersmaK Peter Giese
Mar 22, 2005·Nature Neuroscience·Elaine E IrvineK Peter Giese
Apr 27, 2005·Nature Neuroscience·Thu Jennifer Ngo-AnhJohn P Adelman

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Citations

Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kasia RadwanskaK Peter Giese
May 28, 2009·Learning & Memory·Catherine C Kaczorowski, John F Disterhoft
Jan 15, 2014·Neuropharmacology·Mikael C Guzman-KarlssonJ David Sweatt
May 23, 2007·Aging Cell·John F Disterhoft, M Matthew Oh
Sep 1, 2006·Trends in Neurosciences·John F Disterhoft, M Matthew Oh
Sep 1, 2015·Frontiers in Cellular Neuroscience·Tomasz WójtowiczJerzy W Mozrzymas
Feb 27, 2016·Critical Reviews in Biochemistry and Molecular Biology·Andrew J Kennedy, J David Sweatt
Aug 25, 2016·Science Signaling·Jarrod P MeadowsJohn J Hablitz
Jan 5, 2012·Brain Research Bulletin·M Hasan Mohajeri, K Peter Giese
Sep 11, 2007·Behavioural Brain Research·Edgardo O Alvarez, Pablo A Alvarez
Jan 10, 2018·Genes, Brain, and Behavior·Z HardaK Radwanska
Mar 18, 2009·The European Journal of Neuroscience·James Edgar McCutcheon, Michela Marinelli

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