Differential effects of anti-TNF-α and anti-IL-12/23 agents on human leukocyte-endothelial cell interactions

European Journal of Pharmacology
Cesar Rios-NavarroAngeles Alvarez

Abstract

Enhanced leukocyte recruitment is an inflammatory process that occurs during early phases of the vascular dysfunction that characterises atherosclerosis. We evaluated the impact of anti-TNF-α (adalimumab, infliximab and etanercept) and anti-IL-12/23 (ustekinumab) on interactions between human leukocytes and endothelial cells in a flow chamber that reproduced in vivo conditions. Clinical concentrations of anti-TNF-α were evaluated on the leukocyte recruitment induced by a variety of endothelial (TNF-α, interleukin-1β, lymphotoxin-α and angiotensin-II) and leukocyte (PAF, IL-12 and IL-23) stimuli related to inflammation and atherosclerosis. Treatment with anti-TNF-α, even before or after establishing the inflammatory situation induced by TNF-α, diminished leukocyte-endothelial cell interactions induced by this stimuli. Our results also implicated adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in the actions of anti-TNF-α in terms of leukocyte adhesion to endothelium. However, anti-TNF-α drugs did not influence the actions of interleukin-1β, but prevented those of lymphotoxin-α and angiotensin-II. However, once established, inflammatory response elicited by the latter three stimuli could not be reversed. Pre-treatment with ant...Continue Reading

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Citations

Feb 5, 2016·European Heart Journal·Dimitris TousoulisJuan Carlos Kaski
May 19, 2016·Expert Opinion on Pharmacotherapy·Alexander Egeberg, Lone Skov
Feb 13, 2018·Mediators of Inflammation·Arduino A MangoniGian Luca Erre
Jun 28, 2018·Anais Da Academia Brasileira De Ciências·Ione C P PereiraElizabeth S Fernandes
Nov 26, 2015·American Journal of Clinical Dermatology·Tiago TorresManuela Selores
Sep 10, 2020·International Journal of Molecular Sciences·Elaina Melton, Hongyu Qiu
Jan 10, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Sandra López-DomènechMilagros Rocha
Apr 21, 2020·The Journal of Investigative Dermatology·Patricia García-MartínezIsabel Andújar

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