Dec 30, 2006

Differential effects of antipsychotic drugs on serotonin-1A receptor-mediated disruption of prepulse inhibition

The Journal of Pharmacology and Experimental Therapeutics
Maarten Van den Buuse, Andrea Gogos

Abstract

Serotonin-1A (5-HT(1A)) receptors have been implicated in the symptoms of schizophrenia. However, there is limited in vivo evidence for an interaction of antipsychotic drugs with 5-HT(1A) receptor-mediated behavioral effects. We therefore investigated in rats the action of several antipsychotic drugs on prepulse inhibition (PPI), a measure of sensorimotor gating that is deficient in schizophrenia. Disruption of PPI at the 100-ms interstimulus interval (ISI), but not the 30-ms ISI, was induced by treatment with 0.5 mg/kg 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), the 5-HT(1A) receptor agonist. In rats pretreated with 0.25 mg/kg haloperidol (4-[-4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro butyrophenone) or raclopride [3,5-dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide tartrate], the disruption of PPI was no longer significant. Of the atypical antipsychotic drugs clozapine (8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine), olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine), risperidone [3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one)], amisulpride (4-amino-N-[(1-ethyl-2-py...Continue Reading

Mentioned in this Paper

Amisulpride
Dione
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Assay OF Haloperidol
Olanzapine
Schizophrenia
Serotonin Measurement
Clozapine
Serotonin

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Agnès L AuclairAdrian Newman-Tancredi
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Laurent BardinAdrian Newman-Tancredi
Progress in Neuro-psychopharmacology & Biological Psychiatry
Herbert Y MeltzerJunji Ichikawa
© 2020 Meta ULC. All rights reserved