PMID: 20650075Apr 1, 1995Paper

Differential effects of chemical irritants in rabbit and human skin organ cultures

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Johannes J M van de Sandt, A A Rutten

Abstract

The toxicity of well known irritants was investigated in rabbit and human skin organ cultures. Test chemicals were selected from various categories of irritants and included both water-soluble and water-insoluble compounds. Using a highly standardized protocol, test chemicals were applied topically at concentrations relevant to the in vivo situation. Toxicity was assessed by histomorphological examination, inhibition of conversion of the tetrazolium salt MTT, inhibition of epidermal cell proliferation and release of pro-inflammatory hydroxy fatty acids. Chemicals that are known to induce irritation in vivo invariably caused histopathological changes and inhibition of cell proliferation, whereas non-irritating chemicals did not; however, inhibition of MTT conversion and release of hydroxy fatty acids occurred with only a limited number of irritants. The response to the chemical irritants was different in rabbit and human skin cultures. Rabbit skin was slightly more sensitive to sodium dodecyl sulfate and benzalkonium chloride than human skin. Moreover, mineral oil enhanced epidermal cell proliferation in rabbit skin, but not in human skin. This study demonstrates that chemical irritants cause substance- and species-specific effe...Continue Reading

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Citations

Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R J EspersenE S Rasmussen
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J N Lawrence
Oct 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J N LawrenceD J Benford
Oct 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Roguet, H Schaefer
Oct 18, 2011·Biomedical Chromatography : BMC·C E Serna-JiménezV Merino
Aug 16, 2005·Regulatory Toxicology and Pharmacology : RTP·Harrie E BuistCees de Heer
Jul 22, 2015·International Journal of Pharmaceutics·C E Serna-JiménezV Merino
Mar 21, 2007·Regulatory Toxicology and Pharmacology : RTP·Harrie E BuistJohannes J M van de Sandt
Sep 1, 1999·Alternatives to Laboratory Animals : ATLA·J van de SandtM Fartasch

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