PMID: 9438675Jan 23, 1998Paper

Differential effects of chlordiazepoxide on aggressive behavior in male mice: the influence of social factors

Psychopharmacology
P F FerrariP Palanza

Abstract

The present study examined the influence of prior social experience on the effects of chlordiazepoxide (CDP; 5.0, 10.0 and 20.0 mg/kg) on intrasexual aggression in male mice. Prior to drug testing, animals were either individually housed or screened in dyadic encounters in a neutral cage. This novel method yielded four experimental groups comprising animals with different social experiences and different aggressive/defensive characteristics: 1) individually-housed males (I): 2) aggressive males (A); 3) counter-attacking males (C), which actively responded to but did not initiate attack; and 4) defeated males (D). Twenty-four hours after screening, animals were treated with CDP and subjected to a resident-intruder test with untreated intruders. Results indicated that the lowest dose of CDP (5 mg/kg) increased aggressive behaviour but only in A males. At higher doses (10-20 mg/kg), CDP reduced attacks towards intruders in A, C and I, but not D, males. In A and C males, the antiaggressive action of CDP was associated with a prosocial effect (increased social investigation), whereas in I males, reduced aggression was associated with an increase in fear-related behaviours. As these differential effects of CDP on intermale aggression...Continue Reading

Citations

Jun 5, 2004·Psychoneuroendocrinology·Alessandro BartolomucciPaola Palanza
Nov 12, 2003·Hormones and Behavior·Klaus A MiczekJoseph F De Bold
Apr 12, 2003·Psychoneuroendocrinology·A BartolomucciS Parmigiani
Mar 3, 2005·Journal of Comparative Psychology·Alina S Rusu, Sven Krackow
Nov 17, 2004·Genes, Brain, and Behavior·R Lathe
Apr 1, 2003·CNS Drugs·Torbjörn BäckströmDi Zhu
Feb 14, 2006·Journal of Applied Animal Welfare Science : JAAWS·Therese M PhamVera Baumans
Nov 6, 2008·Molecular and Cellular Endocrinology·Yonghua ZhangAndré Tchernof
Apr 3, 2004·Physiology & Behavior·Takefumi KikusuiYuji Mori
May 9, 2013·Neurological Research·Yanier Nuñez FigueredoGilberto L Pardo Andreu
Jan 8, 2004·The Journal of Veterinary Medical Science·Kayo NakamuraYuji Mori
Mar 11, 2009·Psychoneuroendocrinology·Lotta AndréenTorbjörn Bäckström
Feb 15, 2015·Neuroscience Letters·S LakehayliA Tazi
May 4, 2016·Psychiatry Research·Bonnie AlbrechtDavid Best
Dec 27, 2011·Journal of Clinical Psychopharmacology·Stefano ComaiGabriella Gobbi
Jan 25, 2003·Journal of Sex Research·Damon MitchellRoy S Lilly

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