PMID: 19912867Jun 1, 1992Paper

Differential effects of chronic ethanol administration on GABA(A) receptor alpha1 and alpha6 subunit mRNA levels in rat cerebellum

Molecular and Cellular Neurosciences
A L MorrowP Montpied

Abstract

Chronic ethanol exposure alters muscimol, pentobarbital, and benzodiazepine agonist and inverse agonist effects on the function of GABA(A) receptor-gated Cl(-) channels in the central nervous system (CNS). We have recently shown that prolonged ethanol inhalation reduces the expression of GABA(A) receptor alpha1 and alpha2 subunit mRNAs in the rat cerebral cortex, with no effect on the level of alpha3 subunit transcripts, glutamic acid decarboxylase mRNA levels, or poly(A)(+) RNA levels. In the present study, rats were administered alcohol by liquid diet for 2 weeks using a pair-fed design. GABA(A) receptor alpha subunit mRNA levels were quantified by Northern analysis using specific cRNA probes. GABA(A) receptor alpha1 subunit mRNA levels were reduced in the cerebral cortex to the same extent as previously reported following prolonged ethanol inhalation. In the cerebellum, chronic ethanol ingestion reduced the levels of GABA(A) receptor alpha1 subunit mRNAs (4.8 and 4.4 kb) by 20-30% and increased the levels of GABA(A) receptor a6 subunit mRNA (2.7 kb) by 45%. GABA(A) receptor alpha2 and alpha3 subunit mRNAs were not detected in the cerebellum. Glutamic acid decarboxylase mRNA levels as well as poly(A)(+) RNA levels were not si...Continue Reading

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Citations

Apr 15, 1994·European Journal of Pharmacology·L L Devaud, A L Morrow
Mar 20, 2004·Pharmacology & Therapeutics·Sandeep KumarA Leslie Morrow
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·D B MatthewsA L Morrow
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·L L DevaudA L Morrow
Dec 18, 2001·Brain Research. Brain Research Reviews·A L MorrowD B Matthews
Dec 1, 1996·Neurochemistry International·J M LewohlP R Dodd
Oct 17, 1998·Progress in Neurobiology·F Fadda, Z L Rossetti
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·L L DevaudG E Duncan
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·P Dodd
Nov 5, 1999·Alcoholism, Clinical and Experimental Research·K BlaineS Conway
Jun 19, 2001·Alcoholism, Clinical and Experimental Research·J PetrieR W Olsen
Mar 15, 2005·The Journal of Clinical Investigation·Jason E KralicA Leslie Morrow
Aug 3, 2001·Journal of Neurochemistry·J M LewohlP R Dodd
Jun 9, 2007·Pharmacology & Therapeutics·Giovanni BiggioMariangela Serra
Apr 7, 2015·Pharmacology, Biochemistry, and Behavior·Adelle NovierDouglas B Matthews
May 21, 2016·Frontiers in Cellular Neuroscience·Benjamin FörsteraLuis G Aguayo
Apr 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hugh E Criswell, George R Breese
Feb 4, 2010·Pharmacological Reviews·Mikko Uusi-Oukari, Esa R Korpi
Oct 1, 2019·Journal of Addiction Medicine·Laura B BernsteinMaryann Popiel
Jun 13, 2020·The Journal of Pharmacology and Experimental Therapeutics·Christopher P KnightZachary A Rodd
May 25, 2016·Alcoholism, Clinical and Experimental Research·Adelle NovierDouglas B Matthews
Jan 29, 2020·Cold Spring Harbor Perspectives in Medicine·Marisa RobertoSophia Khom

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