Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy.

Journal of Psychopharmacology
Matthew TaylorJohn Evans

Abstract

The pharmacological effects of monoamine potentiating antidepressants are likely to be expressed ultimately on cortical pyramidal neurones that use glutamate as a neurotransmitter. However, there are few data on the effects of antidepressant treatment on cortical glutamate levels in humans. The aim of the present study was to use proton magnetic resonance spectroscopy (MRS) to assess the effects of short-term administration of the selective serotonin re-uptake inhibitor, citalopram and the selective noradrenaline re-uptake inhibitor, reboxetine, on a composite measure of glutamate and glutamine (Glx) in occipital cortex in healthy volunteers using a parallel group, placebo-controlled design. We found that relative both to placebo and reboxetine, seven days treatment with citalopram significantly increased cortical Glx. Our data suggest that short-term treatment with citalopram, but not reboxetine, increases occipital Glx in healthy subjects. Further studies are needed to find out if similar effects occur in anterior brain regions and whether they reflect changes in glutamate or glutamine or both.

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Mar 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy H PerlisFrancis J McMahon
Dec 11, 2008·Psychiatry and Clinical Neurosciences·Raffaella ZanardiCristina Colombo
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Jan 22, 2010·Nordic Journal of Psychiatry·Ulla Knorr, Lars Vedel Kessing
Mar 15, 2018·Frontiers in Molecular Neuroscience·Boldizsár Czéh, Szilvia A Nagy

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