Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine

Cephalalgia : an International Journal of Headache
G-M KimC-S Chung

Abstract

Nitric oxide (NO) directly activates trigeminal afferents innervating the dura mater and up-regulates inflammatory mediators. We evaluated NO-mediated up-regulation of cyclooxygenase-2 (COX-2), tumour necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-9 (MMP-9), and the effect of glucocorticoid administration in an experimental animal model of migraine. COX-2 and TNF-alpha expression and MMP-9 activity were increased after continuous intravenous infusion of glyceryl trinitrate (GTN), a NO donor. Immunofluorescence staining demonstrated strong expression of these inflammatory mediators in the meningeal blood vessels. Methylprednisolone (MP) down-regulated MMP-9, which was reversed by RU486, a glucocorticoid receptor antagonist. COX-2 and TNF-alpha expression was not affected by MP or RU486 administration. These results suggest proinflammatory mediators are involved in the NO-mediated cascade of migraine pathogenesis. Further understanding of the activation of these inflammatory mediators at the transcriptional level may have therapeutic implications for future migraine treatments.

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Citations

Mar 13, 2014·British Journal of Pharmacology·S E Erdener, T Dalkara
Jan 13, 2015·Cephalalgia : an International Journal of Headache·Y W WoldeamanuelR P Cowan
Oct 17, 2014·Cephalalgia : an International Journal of Headache·Yeon-Jung Kim, Sun U Kwon
Aug 29, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yasemin CayirFatih Akcay
Mar 15, 2019·Current Pain and Headache Reports·Amir RashedAli Pourmand
Nov 12, 2009·Expert Review of Neurotherapeutics·Vinod Kumar Gupta
Jan 12, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Dilek BerkerSerdar Guler
Jul 19, 2011·Rapid Communications in Mass Spectrometry : RCM·Anu Shilpa KrishnatryHo-Leung Fung
Apr 13, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y HuangY Hu
Jan 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chao LiHemin Zhang
Oct 20, 2009·Nitric Oxide : Biology and Chemistry·Anu Shilpa KrishnatryHo-Leung Fung
Dec 16, 2010·Nitric Oxide : Biology and Chemistry·Anu Shilpa KrishnatryHo-Leung Fung

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Laser Sharp2000
Gelpro
SPSS

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