PMID: 9539260Apr 16, 1998Paper

Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats

Psychopharmacology
M RamanathanS K Bhattacharya

Abstract

The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various anxiety paradigms, including the open-field exploratory behaviour, elevated plus maze and elevated zero maze behaviours and the social interaction tests. In addition, rat brain tribulin activity was also assessed as a biochemical marker of anxiety. The results indicate that diabetic rats showed significantly more anxiogenic activity in comparison to non-diabetic rats on open-field, elevated plus maze, zero maze and social interaction tests. In diabetic rats, brain tribulin activity (MAO-A inhibitory component) was significantly increased. DZP dose dependently produced anxiolytic activity on the various behavioural parameters in non-diabetic rats. DZP (0.5 and 1 mg/kg) partially reversed the anxiogenic behaviour of STZ diabetic rats in elevated plus maze and zero maze tests. However, in open field behaviour and social interaction tests significant anxiolytic activity was observed only at a higher dose of DZP (1 mg/kg)...Continue Reading

Citations

Aug 8, 2002·Phytotherapy Research : PTR·A L da SilvaE Elisabetsky
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·L Costa-CamposE Elisabetsky
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Feb 7, 2014·Diabetology & Metabolic Syndrome·Ana Carolina Inhasz KissDébora Cristina Damasceno
Feb 22, 2014·Cellular and Molecular Neurobiology·Debapriya Garabadu, Sairam Krishnamurthy
Mar 9, 2011·Behavioural Brain Research·Robert M DuvoisinJacob Raber
Jul 6, 2010·Neuroscience Letters·Maurizio CasarrubeaGiuseppe Crescimanno
Jul 31, 2010·Pharmacology, Biochemistry, and Behavior·Patrícia Bezerra GomesFrancisca Cléa Florenço de Sousa
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·N LealE Suarez
Oct 23, 2015·Advances in Pharmacological Sciences·Mohamed Naguib ZakariaWaleed Barakat
Aug 16, 2012·Physiology & Behavior·Ana Carolina Inhasz KissDébora Cristina Damasceno
Sep 29, 2011·Physiology & Behavior·Nancy HoIrwin Lucki
Apr 5, 2011·Behavioural Brain Research·Claudia A GrilloLawrence P Reagan
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Jul 5, 2016·Behavioural Brain Research·Daniela Rebolledo-SolleiroMiguel Pérez de la Mora
Apr 4, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L Da Silva, E Elisabetsky
Jan 31, 2017·Journal of Basic and Clinical Physiology and Pharmacology·R RajashreeShivaprasad S Goudar
Mar 28, 2013·Metabolic Brain Disease·Carlos Alberto Yasin WayhsCarmen Regla Vargas
Sep 1, 2018·Archives of Physiology and Biochemistry·Ghazal RahmaniHadi Ebrahimi
Aug 20, 2003·Nature Medicine·Matthew J DuringColin N Haile
Apr 26, 2014·Metabolic Brain Disease·Deepali GuptaYeshwant Kurhe
May 27, 2016·The Journal of Biological Chemistry·Tamami WakabayashiTomoko Kuwabara
Dec 15, 2020·Physiology & Behavior·Zeinab MomeniVerónica A Campanucci
Aug 2, 2021·Physiology & Behavior·Marina Galleazzo MartinsAna Carolina Inhasz Kiss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.