Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease

Particle and Fibre Toxicology
Chelsea A O'DriscollJoshua D Mezrich

Abstract

Exposure to particulate matter (PM) has been associated with increased incidence and severity of autoimmune disease. Diesel PM is primarily composed of an elemental carbon core and adsorbed organic compounds such as polycyclic aromatic hydrocarbons (PAHs) and contributes up to 40% of atmospheric PM. The organic fraction (OF) of PM excludes all metals and inorganics and retains most organic compounds, such as PAHs. Both PM and OF increase inflammation in vitro and aggravate autoimmune disease in humans. PAHs are known aryl hydrocarbon receptor (AHR) ligands. The AHR modulates T cell differentiation and effector function in vitro and in experimental autoimmune encephalomyelitis (EAE), a murine model of autoimmune disease. This study aims to identify whether the total mass or active components of PM are responsible for activating pathways associated with exposure to PM and autoimmune disease. This study tests the hypothesis that active components present in diesel PM and their OF enhance effector T cell differentiation and aggravate autoimmune disease. Two different diesel samples, each characterized for their components, were tested for their effects on autoimmunity. Both diesel PM enhanced effector T cell differentiation in an A...Continue Reading

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Citations

Feb 26, 2019·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Mar 17, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shoresh BarkhordariRoya Kelishadi
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Jul 13, 2021·Frontiers in Cellular Neuroscience·Monika Jankowska-KieltykaIrena Nalepa

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Methods Mentioned

BETA
flow cytometry

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