Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain

Brain Research
B E LevinA A Dunn-Meynell

Abstract

The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this channel has a similar effect. Here rats with a propensity to develop diet-induced obesity (DIO) or to be diet-resistant (DR) when fed a diet moderately high in fat, energy and sucrose (HE diet) had low and high affinity sulfonylurea binding assessed autoradiographically with [3H]glyburide in the presence or absence of Gpp(NH)p. Before HE diet exposure, chow-fed DIO- and DR-prone rats were separated by their high vs. low 24 h urine NE levels. In DR-prone rats, low affinity [3H]glyburide binding sites comprised up to 45% of total binding with highest concentrations in the hypothalamus and amygdala. But DIO-prone rats had few or no low affinity binding sites throughout the forebrain. High affinity [3H]glyburide binding was similar between phenotypes. When rats developed DIO after 3 months on HE diet, their low affinity binding increased slightly. DR rats fed the HE diet gained the same amount of weight as chow-fed contr...Continue Reading

References

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Dec 1, 1991·The American Journal of Physiology·B E Levin
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Jan 1, 1983·Advances in Metabolic Disorders·Y Oomura
May 1, 1995·Pflügers Archiv : European journal of physiology·J Röper, F M Ashcroft
Aug 1, 1994·The American Journal of Physiology·B E Levin
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Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·C Schwanstecher, U Panten
Feb 1, 1996·The American Journal of Physiology·B E Levin

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Citations

Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
Mar 10, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L A Velloso, M W Schwartz
May 9, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Naveen SharmaHong-Won Suh
Jan 1, 1999·Nutritional Neuroscience·D S Roane, J K Bounds
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deborah J CleggBarry E Levin
Oct 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nancy C Tkacs, Barry E Levin
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry E Levin
May 1, 1997·Obesity Research·A A Dunn-Meynell, B E Levin
May 8, 1999·The American Journal of Physiology·B E LevinV H Routh
Feb 10, 1999·The American Journal of Physiology·B E Levin
Apr 20, 1999·Biochemical and Biophysical Research Communications·L GrosP Blache
Sep 23, 1998·Brain Research Bulletin·B E Levin, A A Dunn-Meynell

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