PMID: 6166794Mar 1, 1981Paper

Differential effects of dihydroergotamine on the circulatory actions of arterial and venous dilators in the rat

Journal of Cardiovascular Pharmacology
J E de Metz, P A van Zwieten

Abstract

We attempted to characterize in six vasodilators with respect to their arterial or venous activity by studying their interaction with the circulatory effects of dihydroergotamine (DHE) in phenobarbital-anesthetized rats. DHE is a selective venoconstrictive agent which increases mean arterial pressure (MAP) and cardiac output (CO) in the pithed rat without affecting peripheral resistance (R). In the anesthetized rat the hypotensive effect of venodilators (sodium nitrite, glyceryl trinitrate, and molsidomine) was diminished after pretreatment with DHE, ve venoconstrictive agent which increases mean arterial pressure (MAP) and cardiac output (CO) in the pithed rat without affecting peripheral resistance (R). In the anesthetized rat the hypotensive effect of venodilators (sodium nitrite, glyceryl trinitrate, and molsidomine) was diminished after pretreatment with DHE, ve venoconstrictive agent which increases mean arterial pressure (MAP) and cardiac output (CO) in the pithed rat without affecting peripheral resistance (R). In the anesthetized rat the hypotensive effect of venodilators (sodium nitrite, glyceryl trinitrate, and molsidomine) was diminished after pretreatment with DHE, whereas the decrease in MAP induced by arterial va...Continue Reading

Citations

Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·H L ElliottJ L Reid
Jan 1, 1987·Pharmacotherapy·R E Nitz, V B Fiedler
Sep 1, 1985·Japanese Journal of Pharmacology·Y ShirasawaM Nakamura

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