PMID: 8594810Sep 1, 1995Paper

Differential effects of dopamine depletion on the distribution of [3H]SCH 23390 and [3H]spiperone binding sites in the goldfish retina

Vision Research
S Yazulla, Z S Lin

Abstract

The distributions of dopamine D1 and D2 receptors were studied in intact goldfish retina with in vitro autoradiography. Specific [3H]SCH 23390 binding (D1 receptors) was greatest over the outer plexiform layer (OPL)/horizontal cell bodies and less so over the inner nuclear and inner plexiform layers (IPL). Specific [3H]spiperone binding (D2 receptors) appeared in two bands, over the OPL/horizontal cell bodies and the IPL. Depletion of retinal dopamine, by intraocular injections of 6-hydroxydopamine, had no effect on the pattern and density of [3H]SCH 23390 binding; however, specific [3H]spiperone binding over the OPL and IPL was virtually eliminated, suggestive of D2 autoreceptors on dopamine interplexiform cells. These data are consistent with electrophysiological studies indicating the presence of D1 and D2 receptors in both plexiform layers of the goldfish retina.

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Citations

Apr 15, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·E Popova
Oct 21, 2003·The Journal of Physiology·Christophe RibelaygaStuart C Mangel
Sep 13, 2008·Neuron·Christophe RibelaygaStuart C Mangel
Jul 28, 1999·The Journal of Comparative Neurology·C Mora-FerrerM Haak-Frendscho
Nov 5, 2003·The Journal of Comparative Neurology·Christophe Ribelayga, Stuart C Mangel
Jul 18, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Doh-Yeon Kim, Chang-Sub Jung
Mar 30, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ping LiLei Li
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
Nov 2, 2002·The Journal of Physiology·Christophe RibelaygaStuart C Mangel

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