Differential effects of energy balance on experimentally-induced colitis.

World Journal of Gastroenterology : WJG
Sarah J McCaskeyJenifer I Fenton

Abstract

To characterize the influence of diet-induced changes in body fat on colitis severity in SMAD3-/- mice. SMAD3-/- mice (6-8 wk of age) were randomly assigned to receive a calorie restricted (30% of control; CR), control (CON), or high fat (HF) diet for 20 wk and were gavaged with sterile broth or with Helicobacter hepaticus (H. hepaticus) to induce colitis. Four weeks after infection, mice were sacrificed and the cecum and colons were processed for histological evaluation. Dietary treatment significantly influenced body composition prior to infection (P < 0.05), with CR mice having less (14% ± 2%) and HF-fed mice more body fat (32% ± 7%) compared to controls (22% ± 4%). Differences in body composition were associated with alterations in plasma levels of leptin (HF > CON > CR) and adiponectin (CON > HF ≥ CR) (P < 0.05). There were no significant differences in colitis scores between CON and HF-fed mice 4 wk post-infection. Consistent with this, differences in proliferation and inflammation markers (COX-2, iNOS), and infiltrating cell types (CD3+ T lymphocytes, macrophages) were not observed. Unexpectedly, only 40% of CR mice survived infection with H. hepaticus, with mortality observed as early as 1 wk following induction of coli...Continue Reading

References

Sep 1, 1992·The British Journal of Surgery·A L SheehanN A Shepherd
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G Fernandes, R A Good
May 3, 1996·The Journal of Biological Chemistry·E HuB M Spiegelman
Jul 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H ShimizuM Mori
Aug 15, 1998·Baillière's Clinical Gastroenterology·D S Sanders
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Oct 19, 1999·The Journal of Clinical Investigation·J K HowardS R Bloom
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A Kappes, G Löffler
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R FaggioniC Grunfeld
Jan 26, 2002·Lancet·Fergus Shanahan
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Reinout van CrevelJos W M van der Meer
Mar 9, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A BlainJ Cosnes
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Jean-Philippe BastardBernard Hainque
Jan 15, 2003·Annual Review of Medicine·Stephen D HurstingJ Carl Barrett
Feb 19, 2003·Biochemical and Biophysical Research Communications·Mathias FasshauerRalf Paschke
May 15, 2003·Endocrinology·Christopher J LyonWilla A Hsueh
Oct 22, 2003·Free Radical Research·F Caldefie-ChezetM P Vasson
Oct 23, 2003·Digestive Diseases·Matthias PirlichHerbert Lochs
Feb 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shanthi SitaramanDidier Merlin
Mar 12, 2004·Journal of Gastroenterology and Hepatology·Ahmet TuzunKemal Dagalp
Apr 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Tetsuya TagamiHideshi Kuzuya
May 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Peter MancusoMarc Peters-Golden
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Jun 16, 2005·Diabetes Research and Clinical Practice·Hye Soon ParkRina Yu
Aug 23, 2005·Vitamins and Hormones·Faming ZhangRichard Dimarchi
Aug 24, 2005·Inflammatory Bowel Diseases·Konstantinos KarmirisElias A Kouroumalis
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·R VettorG Federspil
Nov 5, 2005·Circulation Research·Chikaaki KobashiMasashi Kobayashi
Nov 29, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Cristiana E Juge-AubryChristoph A Meier
Jan 21, 2006·Cancer Research·Lillian Maggio-PriceBrian M Iritani
Jan 25, 2006·Inflammatory Bowel Diseases·Konstantinos KarmirisElias A Kouroumalis
Feb 25, 2006·Scandinavian Journal of Gastroenterology·Timothy H J FlorinGraham L Radford-Smith
Apr 6, 2006·Clinical Endocrinology·Tiziana RontiElmo Mannarino
Jun 20, 2006·Best Practice & Research. Clinical Gastroenterology·Maria O'Sullivan, Colm O'Morain
Sep 6, 2006·Gastroenterology·Tamao NishiharaIichiro Shimomura
Jan 30, 2007·Gastroenterology·Raja FayadGiamila Fantuzzi

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Citations

May 31, 2014·BioMed Research International·Jan BilskiTomasz Brzozowski
Jun 4, 2016·Pharmacological Reports : PR·Jan BilskiTomasz Brzozowski
Jun 5, 2016·Experimental Gerontology·Derek M HuffmanNathan K LeBrasseur
Sep 29, 2017·Journal of Clinical Biochemistry and Nutrition·Toshihiko OkadaTaeko Dohi
Feb 20, 2021·Frontiers in Immunology·Abigail R BassonAlex Rodriguez-Palacios

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