Differential effects of estrogen and medroxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women

Endocrine
W B MalarkeyJ K Kiecolt-Glaser

Abstract

We evaluated the influence of continual estrogen replacement therapy (ERT) as presently practiced by postmenopausal women with conjugated estrogens and medroxyprogesterone acetate (MPA) on the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and cellular immunity. Thirty-nine postmenopausal women were evaluated (12 on no replacement, 14 on estrogen only, and 13 on estrogen and MPA). In the women receiving only conjugated estrogens, increased GH levels and decreased IGF-1 levels were found, which replicated previous research and probably reflected estrogen inhibition of hepatic IGF-1 production with a secondary increase in GH release because of reduced feedback inhibition. In women taking both MPA and estrogen, GH was increased and the previously observed estrogen induced decrease in IGF-1 levels was inhibited. In order to determine the influence of ERT on psycho-social stress-induced GH release, math (mental stress) and speech (social stress) challenges were utilized, and they produced significant increases in heart rate in all three groups. The heart rate following stress was significantly enhanced by estrogen replacement. These stressors also led to increased GH secretion in the women taking estrogen and MPA, but n...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·S R LindheimR A Lobo
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·W B MalarkeyR Glaser
Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·B J Van VoorhisJ A Hill
Jul 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·R GlaserJ K Kiecolt-Glaser
Aug 1, 1986·The Journal of Clinical Endocrinology and Metabolism·B Dawson-HughesS Reichlin
Sep 1, 1971·The Journal of Clinical Endocrinology and Metabolism·W B Malarkey, W H Daughaday
Sep 1, 1994·The Journal of Clinical Endocrinology and Metabolism·G Del RioI A MacDonald
Jan 1, 1994·Psychosomatic Medicine·W B MalarkeyR Glaser
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·J K Kiecolt-GlaserJ Sheridan
Jan 1, 1996·Hormone Research·K W KelleyR Dantzer
Jan 1, 1996·Advances in Immunology·R KooijmanR Hooghe
Jun 1, 1996·Cellular and Molecular Neurobiology·J A ChowenJ Argente
Aug 1, 1996·Endocrine Reviews·N J Olsen, W J Kovacs
Oct 1, 1996·The Journal of Clinical Endocrinology and Metabolism·C KirschbaumD H Hellhammer
Jun 1, 1996·The Journal of Clinical Endocrinology and Metabolism·K E FriendM O Thorner

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Citations

Dec 13, 2003·Maturitas·Carlo CampagnoliClementina Peris
Mar 12, 2002·Maturitas·Michele CioffiAnna Maria Molinari
May 24, 2012·Menopause : the Journal of the North American Menopause Society·Nioka C Chisholm, Janice M Juraska
Jan 1, 1997·Annual Review of Psychology·S E TaylorT Seeman
Mar 13, 1999·Annual Review of Psychology·A Baum, D M Posluszny
Mar 13, 1999·Annual Review of Psychology·J T Cacioppo, W L Gardner
Feb 16, 2005·Personality and Social Psychology Review : an Official Journal of the Society for Personality and Social Psychology, Inc·G G Berntson, J T Cacioppo
Dec 6, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Carlo CampagnoliClementina Peris
Jun 30, 2004·Molecular and Cellular Endocrinology·Dominique KoubovecJanet Patricia Hapgood
Apr 19, 2016·Climacteric : the Journal of the International Menopause Society·F AbdiF Ramezani Tehrani
May 25, 2006·Cultural Diversity & Ethnic Minority Psychology·Pamela W Garner
May 10, 2002·Clinical Journal of Oncology Nursing·Susan M Bauer-Wu
Jul 5, 2003·Journal of Endocrinological Investigation·R CozziR Attanasio
Apr 24, 2017·European Journal of Nutrition·Mark Messina, Pamela Magee

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