PMID: 9551685Apr 29, 1998Paper

Differential effects of exogenous and endogenously generated H2O2 on phagocytic activity and glucose release of normal and cirrhotic livers

Journal of Hepatology
H PetermannR Dargel

Abstract

Reactive oxygen species play an essential role in necro-inflammatory processes. Therefore, the aim of the present studies was to investigate the effect of exogenous and endogenously produced H2O2 on the phagocytic capacity and glucose release of perfused cirrhotic rat livers in comparison with that on the controls. Complete septal cirrhosis was achieved by oral treatment of rats with thioacetamide for 6 months. The phagocytic capacity of the perfused livers was measured by the uptake of colloidal carbon. During the continuous perfusion with colloidal carbon, either H2O2 or benzylamine was added to the perfusion medium for a limited time period. The latter functioned as an endogenous H2O2 donor. In control rats exogenous and endogenously produced H2O2 caused a transient stimulation of the hepatic colloidal carbon uptake as well as of the glucose release. Inhibition of the catalase by aminotriazol doubled the changes evoked by H2O2, whereas blockade of the Kupffer cells by GdCl3 drastically reduced its stimulatory effect. Cirrhotic livers took up less colloidal carbon and released lower amounts of glucose than the controls when stimulated by exogenous H2O2. The inhibition of the nitric oxide synthetase augmented the H2O2-induced ...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A P Bautista, J J Spitzer
Dec 1, 1992·Toxicology Letters·H Sies, H de Groot
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ParolaM U Dianzani
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T ZimmermannK Jungermann
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KamimuraH Tsukamoto
Apr 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Matsuoka, H Tsukamoto
Jan 1, 1987·Cell Biochemistry and Function·T ZimmermannR Dargel
Aug 1, 1973·British Journal of Haematology·W G CooksleyJ W Halliday
Dec 1, 1980·The Journal of Pharmacy and Pharmacology·D ParkinsonB A Callingham
Jan 17, 1984·Biochimica Et Biophysica Acta·Y KoshiharaT Tatsuno
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RimolaJ Rodes
Sep 1, 1982·Journal of Clinical Pathology·G HoldstockR Wright
Jul 1, 1995·The Journal of Clinical Investigation·H TsukamotoG M Brittenham
Nov 15, 1994·Annals of the New York Academy of Sciences·W L SmithD L DeWitt
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MurataT Mori
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BedossaM Chojkier
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SuzukiS Baba
May 1, 1996·Alcoholism, Clinical and Experimental Research·A P Bautista, J J Spitzer
Mar 17, 1997·The Journal of Experimental Medicine·R S ByrumB H Koller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
A M GressnerW Tittor
Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
A M Gressner
© 2022 Meta ULC. All rights reserved