PMID: 2497224Apr 1, 1989Paper

Differential effects of FSH and testosterone on the maintenance of spermatogenesis in the adult hypophysectomized rat

The Journal of Endocrinology
J M BartlettE Nieschlag

Abstract

In order to clarify further the role of FSH in the maintenance of spermatogenesis, adult rats were treated with purified human FSH (2 X 5 IU/day per rat), testosterone (1.5 cm silicone elastomer implant) or a combination of both hormones for 2 weeks following hypophysectomy. After hypophysectomy alone, no elongate spermatids were observed and the numbers of pachytene spermatocytes and round spermatids observed were reduced when compared with untreated controls. Testosterone supplementation alone qualitatively maintained the formation of elongate spermatids in most seminiferous tubules, whilst in FSH-treated rats increased numbers of round spermatids and pachytene spermatocytes were observed when compared with hypophysectomized animals. Formation of elongate spermatids, however, did not occur under FSH treatment alone. A combination of FSH and testosterone treatment maintained spermatogenesis in an almost quantitative fashion. Numbers of pachytene spermatocytes and round spermatids were maintained at about 80% of levels seen in intact control animals. Treatment with FSH or testosterone alone maintained testis weights at significantly higher levels than those seen in hypophysectomized controls (FSH, 0.79 +/- 0.05 g; testosterone,...Continue Reading

Citations

Apr 1, 1992·Molecular and Cellular Endocrinology·S KlieschM Parvinen
Jun 1, 1994·Molecular and Cellular Endocrinology·M Loir
Apr 1, 1995·Trends in Endocrinology and Metabolism : TEM·R I McLachlanD M de Kretser
Mar 4, 2000·Domestic Animal Endocrinology·H SauerweinE Schallenberger
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M de KretserN G Wreford
Jan 13, 2000·International Journal of Andrology·M Rocchietti-MarchJ Gromoll
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A Wagner, R Claus
Sep 30, 2006·Human Fertility : Journal of the British Fertility Society·Francis J P EblingJeffrey B Kerr
Jan 1, 1991·Annals of the New York Academy of Sciences·K P Roberts, B R Zirkin
Jan 1, 1991·Annals of the New York Academy of Sciences·G F Weinbauer, E Nieschlag
Feb 5, 2008·Developmental Biology·Maren GodmannRüdiger Behr
Jan 7, 2011·Biology of Reproduction·Payal MitalJannette M Dufour
Aug 5, 2000·Endocrinology·F J EblingJ B Kerr
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Kati L MatthiessonSarah J Meachem
May 1, 2014·Spermatogenesis·Suresh Ramaswamy, Gerhard F Weinbauer
Oct 1, 1992·Molecular and Cellular Endocrinology·L J BlokJ A Grootegoed

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