PMID: 7653256May 1, 1995

Differential effects of gentamicin on the distribution of cochlear function in albino and pigmented guinea pigs

Acta Oto-laryngologica
J W ConleeD J Creel

Abstract

It has been suggested that the high affinity of melanin pigment for aminoglycoside antibiotics may cause these drugs to bind preferentially to the pigmented inner ear, producing greater ototoxicity than in the amelanotic albino cochlea. However, evidence of greater ototoxicity in albinos has led to the hypothesis that melanin inhibits the toxicity of these drugs in the pigmented inner ear. On the other hand, ototoxicity in the pigmented animals may simply be delayed relative to the albinos, only to become equal or even more severe with time. The present study was conducted to determine whether a relatively low dose of gentamicin (68.5 mg/kg) would produce differential ototoxicity between albino and pigmented guinea pigs which would persist long after drug exposure had stopped. Nine pigmented and eight albino guinea pigs were given gentamicin sulfate for 14 consecutive days, and were then allowed a two-month recovery period before cochlear analysis; 11 pairs of saline-injected or untreated albino and pigmented guinea pigs served as controls. The results showed that the gentamicin-treated albinos had significantly elevated thresholds for the compound action potential from the auditory nerve (CAP), and significantly lower endococh...Continue Reading

References

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Jul 1, 1977·Acta Oto-laryngologica·D A Hilding, R D Ginzberg
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·M BarzaA Kane
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Related Concepts

Albinism
Aminoglycoside [EPC]
Gentamicins
Aminoglycosides
Cavia
Gentacycol
Action Potentials
Cochlear Microphonic Potentials
Phaeomelanins
Acoustic Stimulation

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