Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Alina SchrederChristian Koenecke

Abstract

Homing of allogeneic donor T cells to recipient tissue is imperative for the development of acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this study we show that alteration of T cell homing due to integrin-β7 deficiency on T cells or its ligand MAdCAM-1 in BMT recipients contributes to the pathophysiology of experimental GVHD. In contrast, lack of CC chemokine receptor 9 on donor T cells alters tissue homing but does not impact GVHD survival. We further demonstrate that MAdCAM-1 is aberrantly expressed in hepatic murine GVHD as well as in patients with active liver GVHD. However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C M ParkerM B Brenner
Apr 1, 1996·The Journal of Experimental Medicine·A KratzN H Ruddle
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J GrantD H Adams
Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Pavan ReddyGeoffrey R Hill
Jan 8, 2008·Blood·Theo D KimMarcel R M van den Brink
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Christian Koenecke, Reinhold Förster
Sep 15, 2009·European Journal of Immunology·Christian KoeneckeImmo Prinz
May 12, 2012·Nature Reviews. Immunology·Bruce R BlazarMehrdad Abedi
Jun 6, 2012·PloS One·Christian KoeneckeReinhold Förster

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Citations

Nov 2, 2019·Seminars in Immunopathology·Sindhu ThiagarajanKai Hildner

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