PMID: 1208630Sep 1, 1975Paper

Differential effects of intraventricular administration of 6-hydroxydopamine on behavior of rats in approach and avoidance procedures: Reversal of avoidance decrements by diazepam

Pharmacology, Biochemistry, and Behavior
B Beer, L G Lenard

Abstract

The administration of 6-hydroxdopamine (6-HD) and pargyline to rats produced similar selective decreases in responding during the conditioned stimulus (CS) on a discriminated avoidance test where the unconditioned stimulus (US) was shock and on an analogous conditioned approach test where the US was water. Approach behavior during the CS generally recovered, however, while avoidance decrements in the same rats remained for the duration of testing. This suggested that 6-HD-induced avoidance decrement was a result of two independent but interacting processes: (1) a decrease in conditioned behavior as reflected by the similar decrease in responding on both tests; and (2) a hyper-reaction to aversive stimuli that resulted in a tendency to selectively suppress avoidance behavior after the animal received shock. In support of this hypothesis, it was found that 6-HD-induced avoidance decrements could be reversed (1) by treatment with diazpam, a drug that releases suppressed responses; or (2) by delaying avoidance testing until conditioned responding had recovered, thus minimizing the interaction of the two processes.

References

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·L G Lenard, B Beer
Oct 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·E L Bliss, J Ailion
Jun 1, 1974·Journal of Comparative and Physiological Psychology·J L HowardG R Breese
May 1, 1974·Pharmacology, Biochemistry, and Behavior·G E Martin, R D Myers
Jun 4, 1971·Brain Research·H CorrodiL Olson
Mar 14, 1957·Annals of the New York Academy of Sciences·L COOK, E WEIDLEY
Dec 1, 1964·International Journal of Neuropharmacology·C C CHANG

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Citations

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·L G Lenard, B Beer
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·R J BeningerH C Fibiger
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·J R Blackburn, A G Phillips
Oct 1, 1983·Brain Research·R J Beninger
Oct 14, 2014·Frontiers in Behavioral Neuroscience·Xilu JiaoKevin C H Pang
Jul 23, 1999·Toxicology and Industrial Health·B A Sorg, T Hochstatter

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