Differential effects of ketamine and midazolam on heart rate variability

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
T KomatsuY Shimada

Abstract

Alterations in autonomic activity caused by anaesthesia can be assessed by spectral analysis of heart rate variability (HRV). This study examined the effects of ketamine and midazolam on HRV. Thirty patients of ASA PS 1 were studied. Fifteen were given ketamine (2 mg.kg-1) and 15 received midazolam (0.3 mg.kg-1), iv. The RR intervals of ECG were measured before and after induction of anaesthesia for ten minutes during spontaneous respiration. Power spectral density of the data was computed using fast Fourier transform. The spectral peaks within each measurement were calculated: low frequency area (LF, 0.04-0.15 Hz), high frequency area (HF, 0.15-0.5 Hz), and total power (TP, 0.04-0.5 Hz). Normalized unit power was derived as follows: low frequency area (nuLF): LF/TP x 100%, high frequency area (nuHF): HF/TP x 100%. Both ketamine and midazolam caused reductions in all measurements of HRV power (P < 0.05). However, ketamine increased nuLF from 64 +/- 14% to 75 +/- 13% (P < 0.05) and decreased nuHF from 36 +/- 14% to 25 +/- 13% (P < 0.05), while midazolam decreased nuLF from 66 +/- 15% to 54 +/- 14% (P < 0.05) and increased nuHF from 34 +/- 15% to 46 +/- 14% (P < 0.05). These results documented that both ketamine and midazolam red...Continue Reading

References

Mar 19, 1977·Lancet·R I LowensohnE H Hon
Jul 1, 1992·Journal of Clinical Anesthesia·T W LatsonJ M Lipton
Aug 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·T KomatsuY Shimada
Aug 1, 1991·Circulation·A MallianiS Cerutti
Apr 1, 1990·The American Journal of Physiology·S W ChaeC O Lee
Nov 1, 1974·Anesthesia and Analgesia·A D IvankovichB Zahed
Nov 1, 1971·Circulation Research·M N Levy
Feb 1, 1983·Anesthesia and Analgesia·T YamamuraK Furukawa
Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
Nov 1, 1993·Journal of Applied Physiology·T E BrownD L Eckberg

❮ Previous
Next ❯

Citations

Aug 25, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M KawaseY Shimada
May 27, 2008·Journal of Anesthesia·Shyuhei KurashigeMaki Mizogami
Jun 29, 2002·Journal of Clinical Anesthesia·Tomoki NishiyamaKazuo Hanaoka
Jan 6, 2007·Critical Care Medicine·Andriy I BatchinskyLeopoldo C Cancio
Apr 27, 2004·Emergency Medicine Journal : EMJ·M C Howes
Dec 5, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rie TsugayasuTatsuya Ichinohe
Feb 24, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M RistikankareJ Hartikainen
Sep 10, 2014·The Clinical Respiratory Journal·Abdellah Hamed Khalil AliAkira Tangoku
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HoegerB A Yard
Jan 27, 2005·The American Journal of Emergency Medicine·Shigeru SaitoFumio Nishihara
Aug 16, 2015·Autonomic Neuroscience : Basic & Clinical·Jung-Ick ByunKon Chu
Sep 23, 2014·Journal of Clinical Monitoring and Computing·Anne-Louise SmithKaren J Reynolds
Dec 25, 2015·The Australian and New Zealand Journal of Psychiatry·Darryl Bassett
Sep 30, 2010·Korean journal of anesthesiology·Tomoki Nishiyama
Mar 17, 2007·International Journal of Environmental Health Research·Eri Fukuda-MatsudaShigeru Saito
Oct 19, 2017·Journal of Clinical Monitoring and Computing·Nada SabourdinIsabelle Constant
Feb 17, 2007·Pacing and Clinical Electrophysiology : PACE·Jasmin OrtakHendrik Bonnemeier
Oct 11, 2005·European Journal of Anaesthesiology·J PenttiläH Scheinin
Oct 10, 1997·Anesthesia and Analgesia·T KomatsuY Shimada
Feb 8, 2003·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan GaluszkaJana Zapletalová
Sep 29, 2017·Current Opinion in Anaesthesiology·Thomas Anthony Anderson
Mar 16, 2018·Behavioural Pharmacology·Meyrick Kidwell, Bart A Ellenbroek
Oct 12, 2018·Paediatric Anaesthesia·Théa VenetHugues Patural
Nov 4, 2000·Scandinavian Journal of Gastroenterology·M RistikankareJ Hartikainen
Sep 30, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Georgina K CoxAnthony P Farrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.