PMID: 8949815Sep 1, 1996Paper

Differential effects of ketamine and pentobarbitone on acetylcholine release from the rat hippocampus and striatum

British Journal of Anaesthesia
K SatoF Okumura

Abstract

Using microdialysis, we examined the effects of ketamine and pentobarbitone on acetylcholine (ACh) release from the rat hippocampus and striatum. Ketamine 25 and 50 mg kg-1 increased ACh release from the hippocampus to 295% and 353% of basal release, respectively, but not from the striatum. SCH 23390 1 mumol litre-1, a D1 antagonist, significantly inhibited the facilitatory effect of ketamine 50 mg kg-1 on hippocampal ACh release (to 241% of basal level). In contrast, pentobarbitone 20 and 40 mumg kg-1 decreased basal ACh release from both the hippocampus by 41% and 69%, respectively, and the striatum by 37% and 58%, respectively. The results suggest that ketamine and pentobarbitone exert opposite effects on ACh release from the rat hippocampus and that the stimulating effect of ketamine may involve dopamine D1 receptors.

Citations

May 8, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KubotaA Matsuki
Jun 21, 2002·Life Sciences·Fusun BulutcuM Oguz Güç
Sep 18, 2002·Drug and Alcohol Dependence·Michael A TaffeLisa H Gold
Nov 14, 2013·PloS One·Julia D I MeuweseVictor A F Lamme
Oct 13, 2015·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ralf BrischTomasz Gos
Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva
Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Yan-Ping SunJian-Hui Liang
Apr 14, 2006·European Journal of Pharmacology·Klas S P AbelsonA Urban Höglund
Nov 5, 2016·Physiology & Behavior·Katarina LazicJasna Saponjic
Oct 19, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Natalia GassWolfgang Weber-Fahr
Aug 19, 2020·The European Journal of Neuroscience·Ilana Markovich-Molochnikov, Dana Cohen
Feb 29, 2020·Current Neuropharmacology·Xuechao HaoCheng Zhou

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