PMID: 8950013Nov 1, 1996Paper

Differential effects of lidocaine infusions into the ventral CA1/subiculum or the nucleus accumbens on the acquisition and retention of spatial information

Behavioural Brain Research
S B FlorescoA G Phillips

Abstract

Reversible, lidocaine-induced lesions of the CA1/subicular subfield of the ventral hippocampus or the shell region of the nucleus accumbens (N.Acc.) were used to assess the roles of these structure during the acquisition and retention of a spatial response as measured by the Morris water-maze task. Acquisition and retention tests were administered over 2 phases of 6 trials, respectively. Rats receiving reversible lesions of the ventral CA1/subiculum prior to the acquisition phase of this task required significantly longer path lengths to find a hidden platform than animals which received control infusions of artificial cerebrospinal fluid. Rats with similar lesions to the N.Acc. were unimpaired. During the retention phase, 30 min after the acquisition phase, rats with prior ventral CA1/subiculum or N.Acc. lesions had similar path lengths to control animals. Lidocaine infusions into either the ventral CA1/subiculum or N.Acc. prior to the retention phase did not impair performance relative to control animals. These results suggest that the N.Acc. is not involved in either the acquisition or retention of spatial information. In contrast, the ventral CA1/subiculum does appear to be involved in the initial use of novel spatial infor...Continue Reading

References

Apr 1, 1989·Behavioural Brain Research·R J Sutherland, A J Rodriguez
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Aug 1, 1994·The European Journal of Neuroscience·K J Feasey-Truger, G ten Bruggencate
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Jan 1, 1990·The European Journal of Neuroscience·R. G. M. MorrisL. E. Jarrard

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Citations

Jun 15, 2011·Brain Structure & Function·Michael LoureiroAnne Pereira de Vasconcelos
Apr 16, 2004·Behavioural Brain Research·Yolanda D BlackKathleen M Kantak
Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rémi Martin-FardonFriedbert Weiss
Sep 3, 2004·Behavioural Pharmacology·A MeleA Oliverio
Jul 23, 1999·Annals of the New York Academy of Sciences·A E Kelley
Jul 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·G GoldenbergU Arnold
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rutsuko ItoBarry J Everitt
Dec 21, 2010·Behavioural Brain Research·Eiki TakahashiChitoshi Itakura
Jun 28, 2011·Neurobiology of Learning and Memory·Bryan D DevanRobert J McDonald
Jan 16, 1999·Neurobiology of Learning and Memory·C G Ambrogi LorenziniG Tassoni
Mar 16, 2000·Reviews in the Neurosciences·B PoucetP P Lenck-Santini
Oct 2, 2019·Brain and Behavior·Shang Lin Tommy LeeEtan J Markus
Sep 25, 1997·Journal of Neuroscience Research·B Setlow

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