Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis.

Arthritis Research & Therapy
M K BoettgerHans-Georg Schaible

Abstract

Interleukin-6 (IL-6) is a key player in systemic arthritis, involved in inflammation and joint destruction. IL-6 signalling has also been revealed in nerve cells. Recently, IL-6 and in particular IL-6 together with its soluble IL-6 receptor (sIL-6R) were shown to induce a long-lasting robust sensitization of joint nociceptors for mechanical stimuli which was difficult to reverse, suggesting that IL-6 signalling plays a significant role in the generation and maintenance of arthritic pain. Here we tested in a preclinical model of arthritis, antigen-induced arthritis (AIA) in the rat, whether systemic or local neutralization of IL-6/sIL-6R complexes with soluble glycoprotein 130 (sgp130) alters arthritic pain and how sgp130 influences the inflammatory process in AIA. Rats with AIA were either treated with sgp130 or saline intra-peritoneally or intra-articularly (each group n = 9). Then, pain-related and locomotor behaviour, as well as joint swelling, were measured during an observation period of 21 days, followed by histopathological end-point analysis for inflammatory and destructive changes. A single intra-articular application of sgp130 at the time of AIA induction barely reduced the development of AIA, but significantly attenu...Continue Reading

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Citations

Dec 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Olga BraunStefan Rose-John
Nov 12, 2010·Arthritis Research & Therapy·Camilla I Svensson
May 31, 2011·Arthritis Research & Therapy·Michael K BoettgerManuela Schmidt
Jan 28, 2014·Pflügers Archiv : European journal of physiology·Michiel LangeslagMichaela Kress
Jul 17, 2012·Current Rheumatology Reports·Hans-Georg Schaible
Jan 22, 2015·Arthritis Research & Therapy·Hans-Georg Schaible
Jan 17, 2012·Arthritis and Rheumatism·Enrique VazquezAndrea Ebersberger
Apr 19, 2016·Pain Management·Duygu B BasCamilla I Svensson
Jul 30, 2014·Cytokine·Rachel E MillerAnne-Marie Malfait
Apr 27, 2016·Protein Expression and Purification·Xiaozhi ZhaoHongqian Guo
Dec 1, 2017·Rheumatology·Ernest H S Choy, Leonard H Calabrese
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Oct 3, 2020·Mediators of Inflammation·Yanting CaoYiqing Yin
Nov 20, 2016·Temperature : Multidisciplinary Biomedical Journal·Nicole Vargas, Frank Marino
Dec 8, 2020·Current Anesthesiology Reports·Maria F RamirezJuan P Cata
May 23, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Pascale Vergne-Salle, Philippe Bertin

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